Objective. The aim of this study is to investigate the changes and significance of serum C-reactive protein (CRP) and procalcitonin (PCT) levels in patients with acute simple lower urinary tract infection (ALUTI) and to analyze the efficacy of treatment with Shuangdong capsules, so as to provide a basis for the rational clinical application of drugs. Methods. 92 patients with ALUTI (observation group) were randomly divided into 46 cases each in group A and group B. Group A was treated with basic anti-infective drugs, while group B was treated with Shuangdong capsules, and the duration of treatment in both groups was 14 days. The curative effect of the two groups was analyzed, and the changes in serum PCT and CRP levels were compared before and after treatment and compared with 40 healthy people in the control group. Results. The serum PCT and CRP levels, the number of urinary leukocyte count (LEU), and the number of urinary bacterial count (BACT) were significantly higher in Group A and Group B than in the healthy control group before treatment (). After treatment, the total clinical efficiency of patients in group B (97.83%) was significantly higher than that in group A (78.26%) (). The serum PCT and CRP levels, the number of urinary LEU, and the number of urinary BACT decreased in both groups after treatment compared with those before treatment, and all of them were significantly lower in group B than in group A (). The area under the curve (AUC) values of serum PCT and CRP levels for the diagnosis of acute simple lower urinary tract infection were 0.747 (95% CI 0.633–0.860) and 0.926 (95% CI 0.870∼0.982), both with high sensitivity and specificity. Conclusion. The Shuangdong capsule combined with conventional antibacterial drugs has better clinical efficacy in the treatment of acute simple lower urinary tract infection; serum CRP and PCT levels in patients with acute simple lower urinary tract infection can be used as indicators for diagnosis and efficacy determination of the infection.

中文翻译：

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急性单纯性下尿路感染患者血清CRP、PCT水平变化及双动胶囊治疗疗效评价

客观。本研究旨在探讨急性单纯性下尿路感染（ALUTI）患者血清C反应蛋白（CRP）和降钙素原（PCT）水平的变化及意义，分析双冬胶囊治疗的疗效，从而为临床合理用药提供依据。方法. 将92例ALUTI患者（观察组）随机分为A组和B组各46例。A组给予基础抗感染药物治疗，B组给予双冬胶囊治疗，两组治疗时间是14天。分析两组疗效，比较治疗前后血清PCT、CRP水平的变化，并与对照组40名健康人进行比较。结果。A组和B组治疗前血清PCT、CRP水平、尿白细胞计数（LEU）、尿细菌计数（BACT）均显着高于健康对照组。）。治疗后，B组患者临床总有效率（97.83%）明显高于A组（78.26%）（）。治疗后两组血清PCT、CRP水平、尿LEU数、尿BACT数均较治疗前降低，且B组均显着低于A组。）。血清PCT和CRP水平诊断急性单纯性下尿路感染的曲线下面积（AUC）值分别为0.747（95% CI 0.633~0.860）和0.926（95% CI 0.870∼0.982），均具有较高的敏感性和特异性。结论。双冬胶囊联合常规抗菌药物治疗急性单纯性下尿路感染临床疗效较好；急性单纯性下尿路感染患者血清CRP、PCT水平可作为感染诊断及疗效判定的指标。