Abstract

Introduction

Hypospadias is a common congenital abnormality typified by a proximally placed ectopic urethral meatus along the ventral surface of the penis. Androgen receptor (AR) and estrogen receptor (ER) expression in the hypospadias tissues may be altered in hypospadias.

Methodology

We evaluated by immunohistochemistry the AR and ER expression in 75 tissues from hypospadias repair, and compared this expression to that of tissue from 75 patients undergoing circumcision. We also compared the intensity of AR and ER expression between different severities of hypospadias.

Results

AR quantitative grading score decreased with severity of hypospadias, while the ER score increased as the hypospadias worsened, which was statistically significant (p-value <0.05).

Conclusion

The penile tissue AR expression is decreased and ER expression is increased with increasing severity of hypospadias.

中文翻译：

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与正常儿童相比，尿道下裂阴茎组织中雄激素和雌激素受体的定量

摘要

介绍

尿道下裂是一种常见的先天性异常，其典型特征是沿着阴茎腹面的近端异位尿道口。尿道下裂组织中雄激素受体 (AR) 和雌激素受体 (ER) 的表达可能会发生改变。

方法

我们通过免疫组织化学评估了来自尿道下裂修复的 75 个组织中的 AR 和 ER 表达，并将该表达与来自接受包皮环切术的 75 名患者的组织的表达进行了比较。我们还比较了不同严重程度的尿道下裂之间 AR 和 ER 表达的强度。

结果

AR定量分级评分随着尿道下裂的严重程度而降低，而ER评分随着尿道下裂的恶化而升高，具有统计学意义（p值<0.05）。

结论

随着尿道下裂严重程度的增加，阴茎组织 AR 表达减少，ER 表达增加。