Long-acting injectables (LAIs) have made a tremendous impact on clinical medicine. As evidence, dozens of approved LAI products are on the market. These LAI successes, in a large part, came from the clever chemistry of their materials that control drug delivery performance. Beyond their materials, what innovations and technologies led to LAI success? What were the scientific progressions and who were the people and their stories behind LAI success? The answers to these questions are interesting to hear about, learn from, and be inspired by. Many people from many diverse fields contributed to the scientific advancement, product development, and product launches of long-acting injectables. Over 50 years ago, LAI pioneers envisioned a host of new drug delivery concepts and engaged their enthusiasm to reduce their concepts to practice. In doing so, they considered a variety of materials, dosage forms, routes of administration, and manufacturing processes, and they had to devise new tools to support product development. Because of the wide technology breadth of long-acting injectables, this publication focuses on bioabsorbable LAIs formulated with polymeric excipients such as lactide/glycolide functional excipients. Their historical progression of polymer chemistry and formulation development is shared. Successes are highlighted with some backstories.

长效注射剂 (LAI) 对临床医学产生了巨大影响。作为证据，市场上有数十种经批准的 LAI 产品。这些 LAI 的成功在很大程度上来自其控制药物输送性能的材料的巧妙化学。除了他们的材料，还有哪些创新和技术使 LAI 取得了成功？科学进步是什么？LAI 成功背后的人物和故事是谁？这些问题的答案很有趣，值得聆听、学习和启发。来自不同领域的许多人为长效注射剂的科学进步、产品开发和产品发布做出了贡献。50 多年前，LAI 先驱们设想了许多新的药物输送概念，并激发了他们的热情，将他们的概念付诸实践。在这样做，他们考虑了各种材料、剂型、给药途径和制造工艺，并且他们必须设计新的工具来支持产品开发。由于长效注射剂的技术范围很广，本出版物重点介绍了用聚合物赋形剂（例如丙交酯/乙交酯功能性赋形剂）配制的生物可吸收 LAI。他们分享了他们在高分子化学和配方开发方面的历史进展。一些背景故事突出了成功。该出版物重点介绍了用聚合物赋形剂（例如丙交酯/乙交酯功能性赋形剂）配制的生物可吸收 LAI。他们分享了他们在高分子化学和配方开发方面的历史进展。一些背景故事突出了成功。该出版物重点介绍了用聚合物赋形剂（例如丙交酯/乙交酯功能性赋形剂）配制的生物可吸收 LAI。他们分享了他们在高分子化学和配方开发方面的历史进展。一些背景故事突出了成功。