Background

The purpose of this randomized controlled trial was to determine if a one-time dose of vitamin D₃ prior to total knee arthroplasty (TKA) improves function and patient-reported outcomes, while decreasing complications.

Methods

One hundred seven patients undergoing primary TKA were randomized to receive 50,000 international units (IU) vitamin D₃ (57 patients) or placebo (50 patients) on the morning of surgery. Power analysis determined 45 patients were required in each cohort to detect a minimal clinically important difference of six points in the functional component of the 2011 version of the Knee Society Score (KSS), assuming an alpha of 0.05 and power of 80%. KSS and a Timed Up and Go Test (TUGT) were measured preoperatively and at three and six weeks postoperatively.

Results

There was no difference in improvement of KSS at three weeks (+4.8 points vitamin D₃ vs. +3.0 points placebo; p= 0.6) or six weeks (+14.5 points vitamin D₃ vs. +12.4 points placebo; p= 0.5) from baseline. There was no difference in change in TUGT at three weeks (+1.2 seconds vitamin D₃ vs. +0.6 seconds placebo; p=0.6) or six weeks (-0.3 seconds vitamin D₃ vs. -0.9 seconds placebo; p=0.6) from baseline. There were four complications in the placebo cohort within the first 90 days postoperatively and five complications in the vitamin D₃ cohort (p=1.0).

Conclusion

Supplementation with 50,000 IU vitamin D₃ on the day of surgery failed to demonstrate significant differences in functional KSS, TUGT times, or complications in the early postoperative period compared to placebo.

中文翻译：

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全膝关节置换术前补充维生素 D3：一项随机对照试验

背景

这项随机对照试验的目的是确定在全膝关节置换术 (TKA) 之前一次性服用维生素 D _{3是否可以改善功能和患者报告的结果，同时减少并发症。}

方法

接受初次 TKA 的 107 名患者在手术当天被随机分配接受 50,000 国际单位 (IU) 维生素 D _{3 （57 名患者）或安慰剂（50 名患者）。}假设 alpha 为 0.05，功效为 80%，功效分析确定每个队列中需要 45 名患者才能检测到 2011 年版膝关节协会评分 (KSS) 功能成分中 6 分的最小临床重要差异。术前和术后三周和六周测量了 KSS 和定时起步测试 (TUGT)。

结果

三周（+4.8 点维生素 D ₃与 +3.0 点安慰剂；p= 0.6）或六周（+14.5 点维生素 D ₃与 +12.4 点安慰剂；p= 0.5）的 KSS 改善没有差异从基线。三周（+1.2 秒维生素 D ₃对比 +0.6 秒安慰剂；p=0.6）或六周（-0.3 秒维生素 D ₃对比 -0.9 秒安慰剂；p=0.6）时 TUGT 的变化没有差异从基线。术后前 90 天内安慰剂组有 4 例并发症，维生素 D ₃组有 5 例并发症 (p=1.0)。

结论

与安慰剂相比，在手术当天补充 50,000 IU 维生素 D _{3未能证明功能性 KSS、TUGT 时间或术后早期并发症有显着差异。}