Here a fully continuous flow strategy for the preparation of Fe₃O₄@nSiO₂@mSiO₂ nanocomposites starting from ferrous and ferric ions was established for the first time. The three synthetic steps for Fe₃O₄ core, nonporous silica middle shell and mesoporous silica outer shell were connected and integrated into a single flow sequence with a total residence time of approximately 3 min. Moreover, the multistep continuous flow system was simplified with smaller footprint and increased safety by feeding all the ammonia needed by the three synthetic steps only once at the starting point of the system. The final product Fe₃O₄@nSiO₂@mSiO₂ nanoparticles with a specific surface area 378 m² g⁻¹ and saturation magnetization 19.3 emu g⁻¹ showed great potential as a catalyst support with easy and excellent recyclability. Proved to be capable of achieving fast and accurate parameter optimization, the uninterrupted continuous flow system proposed in this work holds great prospects to mediate multistep synthesis of complex nanoparticles with hierarchical structures in an efficient and controllable manner.

在这里，首次建立了从亚铁和铁离子开始制备 Fe ₃ O ₄ @nSiO ₂ @mSiO ₂纳米复合材料的完全连续流动策略。Fe ₃ O ₄核、无孔二氧化硅中间壳和介孔二氧化硅外壳的三个合成步骤被连接并整合成一个总停留时间约为3分钟的单一流动序列。此外，多步连续流动系统得到了简化，占地面积更小，并且通过在系统的起点仅供给三个合成步骤所需的所有氨气，从而提高了安全性。最终产物 Fe ₃ O ₄ @nSiO₂ @mSiO _{2纳米颗粒具有378 m} ²  g ^-1的比表面积和19.3 emu g ^-1的饱和磁化强度，显示出作为催化剂载体的巨大潜力，具有易于回收和优异的可回收性。证明能够实现快速和准确的参数优化，这项工作中提出的不间断连续流动系统在以有效和可控的方式介导具有层次结构的复杂纳米粒子的多步合成方面具有广阔的前景。