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A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow
Chemical Communications ( IF 4.9 ) Pub Date : 2022-08-18 , DOI: 10.1039/d2cc03248a
Bing Lu 1 , Zhecheng Zhang 1 , Yuying Huang 1 , Yuehua Zhang 1 , Jin Wang 1 , Yue Ding 1 , Yang Wang 1 , Yong Yao 1
Affiliation  

In the current work, we synthesized an A–D–A smallmolecule photosensitizer, denoted as DPTTIC, and a dual PEG-functionalized pillararene, denoted as WP5-8C-2PEG, and used them to construct novel DPTTIC nanoparticles (NPs) displaying NIR II absorption. Under 980 nm-wavelength laser irradiation, DPTTIC NPs performed well in mild-temperature photothermal and type I & II photodynamic anti-tumor therapy.

中文翻译:

NIR-II 生物窗中用于温和温度光热和 I 型和 II 型光动力疗法的纳米平台

在目前的工作中,我们合成了一种 A-D-A 小分子光敏剂,记为 DPTTIC,和一种双 PEG 功能化的柱芳烃,记为 WP5-8C-2PEG,并用它们构建了显示 NIR II 的新型 DPTTIC 纳米颗粒 (NPs)吸收。在 980 nm 波长的激光照射下,DPTTIC NPs 在温和的温度光热和 I 型和 II 型光动力抗肿瘤治疗中表现良好。
更新日期:2022-08-18
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