Systemic inflammation is associated with skeletal muscle atrophy and metabolic dysfunction. Although the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contributes to cytokine production in immune cells, its role in skeletal muscle is poorly understood. Here, we studied the link between inflammation, NLRP3, muscle morphology, and metabolism in in vitro cultured C2C12 myotubes, independent of immune cell involvement.

中文翻译：

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NLRP3 炎症小体有助于炎症诱导的骨骼肌形态和代谢改变

全身性炎症与骨骼肌萎缩和代谢功能障碍有关。尽管含有 3 (NLRP3) 炎性体的核苷酸结合寡聚化结构域样受体家族 pyrin 结构域有助于免疫细胞中细胞因子的产生，但其在骨骼肌中的作用知之甚少。在这里，我们研究了体外培养的 C2C12 肌管中炎症、NLRP3、肌肉形态和代谢之间的联系，与免疫细胞的参与无关。