Abstract

Objective

To determine the association of placental pathology with the severity of necrotizing enterocolitis (NEC) in preterm infants.

Methods

This single-center matched case-control study included infants with NEC (n = 107) and gestational age and birth weight-matched controls (n = 130), born between 2013 and 2020. Placentas were evaluated according to the Amsterdam Placental Workshop Group Consensus Statement.

Results

Acute histologic chorioamnionitis with the fetal response was significantly more common in infants with surgical NEC vs. medical NEC (35.4% vs. 15.3%; p = 0.02). On regression model, infants with multiple placental pathologies (OR 2.16; 95% CI 1.01 − 4.73; p = 0.04) and maternal vascular malperfusion (OR 2.2; 95% CI 1.12 − 4.51; p = 0.02) had higher odds of either medical or surgical NEC than controls.

Conclusion

Infants with multiple placental lesions, including placental inflammatory and vascular lesions, were at higher risk of medical or surgical NEC in the postnatal period.

中文翻译：

---

胎盘病理结果与早产儿坏死性小肠结肠炎严重程度的关联——匹配病例对照研究

摘要

客观的

确定胎盘病理学与早产儿坏死性小肠结肠炎 (NEC) 严重程度的关联。

方法

这项单中心匹配病例对照研究包括 2013 年至 2020 年间出生的 NEC 婴儿 ( n  = 107) 以及胎龄和出生体重匹配对照 ( n  = 130)。胎盘根据阿姆斯特丹胎盘研讨会小组共识进行评估陈述。

结果

具有胎儿反应的急性组织学绒毛膜羊膜炎在手术 NEC 婴儿与内科 NEC 婴儿中明显更常见（35.4% 对 15.3%；p  = 0.02）。在回归模型中，患有多胎盘病变（OR 2.16；95% CI 1.01 − 4.73；p  = 0.04）和母体血管灌注不良（OR 2.2；95% CI 1.12 − 4.51；p  = 0.02）的婴儿有更高的医学或手术 NEC 高于对照组。

结论

有多处胎盘病变（包括胎盘炎症和血管病变）的婴儿在产后发生内科或外科 NEC 的风险较高。