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The Na + /H + antiporter SALT OVERLY SENSITIVE 1 regulates salt compensation of circadian rhythms by stabilizing GIGANTEA in Arabidopsis
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2022-08-08 , DOI: 10.1073/pnas.2207275119
Joon-Yung Cha 1, 2 , Jeongsik Kim 3, 4 , Song Yi Jeong 1 , Gyeong-Im Shin 1 , Myung Geun Ji 1, 2 , Ji-Won Hwang 1 , Laila Khaleda 1 , Xueji Liao 1 , Gyeongik Ahn 2 , Hee-Jin Park 5 , Dong Young Kim 6 , Jose M. Pardo 7 , Sang Yeol Lee 1 , Dae-Jin Yun 8, 9 , David E. Somers 4 , Woe-Yeon Kim 1, 2
Affiliation  

The circadian clock is a timekeeping, homeostatic system that temporally coordinates all major cellular processes. The function of the circadian clock is compensated in the face of variable environmental conditions ranging from normal to stress-inducing conditions. Salinity is a critical environmental factor affecting plant growth, and plants have evolved the SALT OVERLY SENSITIVE (SOS) pathway to acquire halotolerance. However, the regulatory systems for clock compensation under salinity are unclear. Here, we show that the plasma membrane Na + /H + antiporter SOS1 specifically functions as a salt-specific circadian clock regulator via GIGANTEA (GI) in Arabidopsis thaliana . SOS1 directly interacts with GI in a salt-dependent manner and stabilizes this protein to sustain a proper clock period under salinity conditions. SOS1 function in circadian clock regulation requires the salt-mediated secondary messengers cytosolic free calcium and reactive oxygen species, pointing to a distinct regulatory role for SOS1 in addition to its function as a transporter to maintain Na + homeostasis. Our results demonstrate that SOS1 maintains homeostasis of the salt response under high or daily fluctuating salt levels. These findings highlight the genetic capacity of the circadian clock to maintain timekeeping activity over a broad range of salinity levels.

中文翻译:

Na + /H + 逆向转运蛋白 SALT OVERLY SENSITIVE 1 通过稳定拟南芥中的 GIGANTEA 调节昼夜节律的盐补偿

生物钟是一种计时、稳态系统,可以在时间上协调所有主要的细胞过程。生物钟的功能在面对从正常到压力诱发条件的可变环境条件下得到补偿。盐度是影响植物生长的关键环境因素,植物已经进化出盐度过度敏感 (SOS) 途径以获得耐盐性。然而,盐度下时钟补偿的调节系统尚不清楚。在这里,我们表明质膜 Na+/H+反向转运蛋白 SOS1 通过 GIGANTEA (GI) 在拟南芥. SOS1 以盐依赖性方式直接与 GI 相互作用,并稳定该蛋白质以在盐度条件下维持适当的时钟周期。SOS1 在生物钟调节中的功能需要盐介导的次级信使胞质游离钙和活性氧物质,这表明 SOS1 除了作为转运蛋白维持钠离子的功能外,还具有独特的调节作用+稳态。我们的结果表明,SOS1 在高盐或每日波动的盐水平下维持盐反应的稳态。这些发现突出了生物钟的遗传能力,可以在广泛的盐度水平范围内保持计时活动。
更新日期:2022-08-08
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