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Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
Diabetes ( IF 7.7 ) Pub Date : 2022-08-16 , DOI: 10.2337/db22-0168
Jinrui Cui 1 , Gautam Ramesh 2 , Martin Wu 3 , Elizabeth T Jensen 4 , Osa Crago 4 , Alain G Bertoni 4 , Chunxu Gao 5 , Kristi L Hoffman 5 , Patricia A Sheridan 6 , Kari E Wong 6 , Alexis C Wood 7 , Yii-Der I Chen 8 , Jerome I Rotter 8 , Joseph F Petrosino 5 , Stephen S Rich 9 , Mark O Goodarzi 1
Affiliation  

Gut microbiome studies have documented depletion of butyrate-producing taxa in type 2 diabetes. We analyzed associations between butyrate-producing taxa and detailed measures of insulin homeostasis whose dysfunction underlies diabetes in 224 non-Hispanic Whites and 129 African Americans, all of whom completed an oral glucose tolerance test. Stool microbiome was assessed by whole metagenome shotgun sequencing with taxonomic profiling. We examined associations between 36 butyrate-producing taxa (7 genera, 29 species) and insulin sensitivity, insulin secretion, disposition index, insulin clearance, and prevalence of dysglycemia (prediabetes plus diabetes, 46% of cohort), adjusting for age, sex, body mass index, and race. Genus Coprococcus was associated with higher insulin sensitivity (β=0.14, P=0.002) and disposition index (β=0.12, P=0.012) and a lower rate of dysglycemia (odds ratio 0.91, 95% confidence interval (CI) 0.85-0.97, P=0.0025); in contrast, Flavonifractor was associated with lower insulin sensitivity (β=-0.13, P=0.004) and disposition index (β=-0.11, P=0.04) and higher prevalence of dysglycemia (OR 1.22, 95% CI 1.08-1.38, P=0.0013). Species-level analyses found 10 bacteria associated with beneficial directions of effects and two bacteria with adverse associations on insulin homeostasis and dysglycemia. While most butyrate-producers analyzed appear to be metabolically beneficial, this is not the case for all such bacteria, suggesting that microbiome-directed therapeutic measures to prevent or treat diabetes should be targeted to specific butyrate-producing taxa rather than all butyrate producers.

中文翻译:

产生丁酸的细菌和胰岛素稳态:微生物组和胰岛素纵向评估研究 (MILES)

肠道微生物组研究记录了 2 型糖尿病中产生丁酸盐的类群的消耗。我们分析了 224 名非西班牙裔白人和 129 名非裔美国人中产生丁酸的类群与胰岛素稳态的详细测量之间的关联,胰岛素稳态的功能障碍是糖尿病的基础,所有这些人都完成了口服葡萄糖耐量测试。通过全宏基因组鸟枪法测序和分类学分析来评估粪便微生物组。我们研究了 36 个产生丁酸的类群(7 个属,29 个物种)与胰岛素敏感性、胰岛素分泌、处置指数、胰岛素清除率和血糖异常患病率(糖尿病前期加糖尿病,占队列的 46%)之间的关联,并根据年龄、性别、体重指数和种族。粪球菌属与较高的胰岛素敏感性(β=0.14,P=0.002)和处置指数(β=0.12,P=0)相关。012)和较低的血糖异常发生率(比值比 0.91,95% 置信区间 (CI) 0.85-0.97,P=0.0025);相反,Flavonifractor 与较低的胰岛素敏感性(β=-0.13,P=0.004)和处置指数(β=-0.11,P=0.04)以及较高的血糖异常患病率相关(OR 1.22,95% CI 1.08-1.38,P =0.0013)。物种水平分析发现 10 种细菌与有益的作用方向相关,两种细菌与胰岛素稳态和血糖异常相关。虽然分析的大多数丁酸生产者似乎对代谢有益,但并非所有此类细菌都是如此,这表明预防或治疗糖尿病的微生物组导向治疗措施应针对特定的丁酸生产者,而不是所有丁酸生产者。85-0.97, P=0.0025); 相反,Flavonifractor 与较低的胰岛素敏感性(β=-0.13,P=0.004)和处置指数(β=-0.11,P=0.04)以及较高的血糖异常患病率相关(OR 1.22,95% CI 1.08-1.38,P =0.0013)。物种水平分析发现 10 种细菌与有益的作用方向相关,两种细菌与胰岛素稳态和血糖异常相关。虽然分析的大多数丁酸生产者似乎对代谢有益,但并非所有此类细菌都是如此,这表明预防或治疗糖尿病的微生物组导向治疗措施应针对特定的丁酸生产者,而不是所有丁酸生产者。85-0.97, P=0.0025); 相反,Flavonifractor 与较低的胰岛素敏感性(β=-0.13,P=0.004)和处置指数(β=-0.11,P=0.04)以及较高的血糖异常患病率相关(OR 1.22,95% CI 1.08-1.38,P =0.0013)。物种水平分析发现 10 种细菌与有益的作用方向相关,两种细菌与胰岛素稳态和血糖异常相关。虽然分析的大多数丁酸生产者似乎对代谢有益,但并非所有此类细菌都是如此,这表明预防或治疗糖尿病的微生物组导向治疗措施应针对特定的丁酸生产者,而不是所有丁酸生产者。04)和血糖异常患病率较高(OR 1.22,95% CI 1.08-1.38,P=0.0013)。物种水平分析发现 10 种细菌与有益的作用方向相关,两种细菌与胰岛素稳态和血糖异常相关。虽然分析的大多数丁酸生产者似乎对代谢有益,但并非所有此类细菌都是如此,这表明预防或治疗糖尿病的微生物组导向治疗措施应针对特定的丁酸生产者,而不是所有丁酸生产者。04)和血糖异常患病率较高(OR 1.22,95% CI 1.08-1.38,P=0.0013)。物种水平分析发现 10 种细菌与有益的作用方向相关,两种细菌与胰岛素稳态和血糖异常相关。虽然分析的大多数丁酸生产者似乎对代谢有益,但并非所有此类细菌都是如此,这表明预防或治疗糖尿病的微生物组导向治疗措施应针对特定的丁酸生产者,而不是所有丁酸生产者。
更新日期:2022-08-16
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