Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC,Alzheimer's & Dementia

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Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-08-15 , DOI: 10.1002/alz.12763
Michel J Grothe _{1,

2,

3} , Alexis Moscoso ₃ , Jesús Silva-Rodríguez ₁ , Catharina Lange ₄ , Kwangsik Nho ₅ , Andrew J Saykin ₅ , Peter T Nelson ₆ , Michael Schöll _{3,

7} , Ralph Buchert ₈ , Stefan Teipel _{2,

9} ,

Affiliation

Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Wallenberg Center for Molecular and Translational Medicine and Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Nuclear Medicine, Berlin, Germany.
Indiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sanders-Brown Center on Aging and Department of Pathology, University of Kentucky, Lexington, Kentucky, USA.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.

Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients.

中文翻译：

基于尸检确认的 LATE-NC 的 FDG-PET 特征对遗忘性痴呆患者的鉴别诊断

边缘系统年龄相关的 TDP-43 脑病神经病理改变 (LATE-NC) 在高龄人群中很常见，可能是类似阿尔茨海默病 (AD) 的临床表现的基础。我们研究了 LATE-NC 尸检衍生的氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET) 特征是否为遗忘性痴呆患者的鉴别诊断提供临床实用性。

更新日期：2022-08-15

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