Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis,Hepatology

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Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis
Hepatology ( IF 13.5 ) Pub Date : 2022-08-16 , DOI: 10.1002/hep.32731
Dimitri Loureiro _{1,

2} , Issam Tout _{1,

2} , Stéphanie Narguet _{1,

2} , Cheikh Mohamed Bed _{1,

2} , Morgane Roinard _{1,

2} , Ahmad Sleiman _{1,

2} , Nathalie Boyer _{1,

2} , Nathalie Pons-Kerjean ₃ , Corinne Castelnau _{1,

2} , Nathalie Giuly _{1,

2} , Dorothy Tonui _{1,

2} , Vassili Soumelis _{4,

5} , Jamel El Benna ₁ , Patrick Soussan ₆ , Richard Moreau _{1,

2} , Valérie Paradis _{1,

2} , Abdellah Mansouri _{1,

2} , Tarik Asselah _{1,

2}

Affiliation

Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters mitochondria in experimental models. Our goal was to investigate whether HBV might alter liver mitochondria also in humans, and the resulting mitochondrial stress might account for the progression of fibrosis in chronic hepatitis B (CHB).

中文翻译：

与慢性乙型肝炎、慢性丙型肝炎或非酒精性脂肪性肝炎相关的晚期纤维化和肝硬化的线粒体应激

乙型肝炎病毒 (HBV) 感染会导致氧化应激 (OS) 并改变实验模型中的线粒体。我们的目标是研究 HBV 是否也可能改变人类的肝线粒体，由此产生的线粒体应激可能是慢性乙型肝炎 (CHB) 纤维化进展的原因。

更新日期：2022-08-16

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