Powering implanted medical devices (IMDs) is still a challenge since the biological system requires biocompatible, stable, and miniaturized electrical power sources. Making use of the salinity gradient is an attractive and efficient way to generate power. Here, we demonstrate the ion-channel-mimetic negatively charged bacterial cellulose (NBC)/MXene nanofluidic membrane as an osmotic nanopower generator. The introduction of NBC nanofibers into MXene nanosheets brings space charge and enhances ion flux. Considering the in vivo application, saline gelatin hydrogels are used as solid electrolytes for the first time. Benefiting from the combination of one-dimensional (1D) nanofibers and two-dimensional (2D) MXene sheets, a power density of 2.58 W m⁻² is obtained under a 100-fold concentration gradient of solid electrolyte. This work demonstrates that salinity energy conversion can also be achieved using solid electrolytes. Moreover, the results of in vitro and in vivo evaluations demonstrate the good biocompatibility of the hybrid membranes. The high-performance osmotic energy conversion and good biocompatibility of the NBC/MXene membrane make it a promising tissue-integrated battery for powering implanted medical devices.

为植入式医疗设备 (IMD) 供电仍然是一项挑战，因为生物系统需要生物相容、稳定和小型化的电源。利用盐度梯度是一种有吸引力且有效的发电方式。在这里，我们展示了离子通道模拟负电荷细菌纤维素 (NBC)/MXene 纳米流体膜作为渗透纳米发电机。将 NBC 纳米纤维引入 MXene 纳米片会带来空间电荷并增强离子通量。考虑到体内应用，盐水明胶水凝胶首次用作固体电解质。受益于一维 (1D) 纳米纤维和二维 (2D) MXene 片材的组合，功率密度为 2.58 W m ^-2是在固体电解质的 100 倍浓度梯度下获得的。这项工作表明，使用固体电解质也可以实现盐分能量转换。此外，体外和体内评估的结果表明混合膜具有良好的生物相容性。NBC/MXene 膜的高性能渗透能转换和良好的生物相容性使其成为为植入式医疗设备供电的有前途的组织集成电池。