A practical and mild multicomponent approach for 3-heterocyclation 2-trifluoromethylation of indoles with quinoxalin-2(1H)-ones and CF₃SO₂Na was reported by using low-cost and catalytic amount of CuF₂ as the catalyst. Various indoles and quinoxalin-2(1H)-ones were well tolerated and the desired products were obtained. Moreover, morphological study indicated hydrochloride 6-CO₂Me derivative was capable to induce apoptosis of A549 cancer cells.

中文翻译：

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铜催化多组分反应构建含氟吲哚-喹喔啉-2(1H)-酮及其生物学评价

通过使用低成本和催化量的 CuF ₂作为催化剂，报道了一种实用且温和的多组分方法，用于吲哚与 quinoxalin-2(1 H )-ones 和 CF ₃ SO ₂ Na的 3-杂环化 2-三氟甲基化。各种吲哚和quinoxalin-2(1 H )-ones 耐受性良好，获得了所需的产品。此外，形态学研究表明盐酸盐6-CO ₂ Me 衍生物能够诱导A549癌细胞凋亡。