当前位置: X-MOL 学术Rheumatology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis
Rheumatology ( IF 5.5 ) Pub Date : 2022-08-12 , DOI: 10.1093/rheumatology/keac465
Haleigh Inthavong 1 , Kamala Vanarsa 1 , Jessica Castillo 1 , M John Hicks 2 , Chandra Mohan 1 , Scott E Wenderfer 3
Affiliation  

Objective The objective of this study was to evaluate the utility of urine CD163 for detecting disease activity in childhood-onset systemic lupus erythematosus (cSLE) patients. Methods Sixty consecutive pediatric patients fulfilling ≥ 4 ACR criteria for SLE and twenty healthy controls were recruited for testing of urinary CD163 using enzyme linked immunosorbent assay. SLE disease activity was assessed using SLEDAI-2000. Results Urine CD163 was significantly higher in patients with active lupus nephritis than inactive SLE patients and healthy controls, with ROC AUC values ranging from 0.93–0.96. Lupus nephritis was ascertained by kidney biopsy. Levels of CD163 significantly correlated strongly with SLEDAI, renal SLEDAI, urinary protein excretion, and C3 complement levels. Urine CD163 was also associated with high renal pathology activity index and chronicity index, correlating strongly with interstitial inflammation and interstitial fibrosis based on examining concurrent kidney biopsies. Conclusion Thus, urine CD163 emerges as a promising marker for identifying cSLE patients with active kidney disease. Longitudinal studies are warranted to validate the clinical utility of urine CD163 in tracking kidney disease activity in children with lupus.

中文翻译:

尿 CD163 是儿童期狼疮性肾炎活动性肾病的标志物

目的 本研究的目的是评估尿液 CD163 在检测儿童期系统性红斑狼疮 (cSLE) 患者疾病活动中的效用。方法 招募 60 名符合 SLE ≥ 4 ACR 标准的连续儿科患者和 20 名健康对照者,使用酶联免疫吸附法检测尿 CD163。使用 SLEDAI-2000 评估 SLE 疾病活动性。结果活动性狼疮肾炎患者的尿 CD163 显着高于非活动性 SLE 患者和健康对照,ROC AUC 值范围为 0.93-0.96。通过肾活检确定狼疮性肾炎。CD163 水平与 SLEDAI、肾脏 SLEDAI、尿蛋白排泄和 C3 补体水平显着相关。尿液 CD163 还与高肾脏病理活动指数和慢性指数相关,根据检查并发肾活检,与间质炎症和间质纤维化密切相关。结论 因此,尿液 CD163 有望成为识别患有活动性肾病的 cSLE 患者的有希望的标志物。有必要进行纵向研究来验证尿液 CD163 在追踪狼疮儿童肾脏疾病活动方面的临床效用。
更新日期:2022-08-12
down
wechat
bug