Liquid biopsy is rapidly growing into a hot research field due to its unique advantages of minimal invasiveness, and extracellular vesicle (EVs) are also expected to become an important pillar in the diagnostic technology system as a newly discovered active substance carrier. More and more research has highlighted the important contribution of EVs in the progress of tumor. Molecular changes during disease progression could be detected in EVs. However, the diagnostic applications of EVs are not generally understood. Combined with the characteristics of hepatobiliary and pancreatic tumor, we summarized the recent developments in various omics analysis of EVs. Furtherly, we explored the role of EVs in the early diagnosis of hepatobiliary and pancreatic tumors by multi-omics analysis.

液体活检以其微创的独特优势迅速成长为研究热点，而细胞外囊泡（EVs）作为新发现的活性物质载体也有望成为诊断技术体系的重要支柱。越来越多的研究强调了电动汽车在肿瘤进展中的重要贡献。可以在 EV 中检测到疾病进展过程中的分子变化。然而，电动汽车的诊断应用并不普遍。结合肝胆胰肿瘤的特点，我们总结了EVs各种组学分析的最新进展。此外，我们通过多组学分析探讨了 EV 在肝胆和胰腺肿瘤早期诊断中的作用。