Objective The aim of this study was to test the extent to which physical activity performed during work and leisure is associated with systemic inflammation. Methods Data regarding job history and high-sensitivity C reactive protein (hs-CRP) levels, as well as potential confounders, came from the Copenhagen Aging and Midlife Biobank. The participants’ self-reported job history was combined with a job exposure matrix to give a more valid assessment of cumulated occupational physical activity compared with conventional self-reported activity. Occupational physical activity was measured as cumulative ton-years (lifting 1000 kg each day for a year). Current leisure time physical activity was self-reported into four different categories. We analysed the association between occupational physical activity, current leisure time physical activity and hs-CRP level in a multivariable linear regression model with adjustment for age, sex, smoking history, number of chronic diseases, body mass index and alcohol. Results In unadjusted analysis, higher occupational physical activity was associated with increased hs-CRP levels, while higher leisure time physical activity was associated with lower hs-CRP levels. In adjusted analysis, lower leisure time physical activity resulted in 12% higher hs-CRP levels while higher occupational physical activities showed a 6% increase in hs-CRP. When we analysed occupational and leisure time physical activity as continuous variables, only leisure time physical activity affected hs-CRP. Conclusion This study indicates that the relationship between physical activity and hs-CRP depends on the setting of physical activity, with lower hs-CRP related to leisure time physical activity and higher hs-CRP related to occupational physical activity. The results suggest that systemic inflammation may explain the physical activity paradox. Data are available upon reasonable request. Request are made to the PI of CAMB. More information is available from .

中文翻译：

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身体活动悖论：炎症可能是关键因素吗？

目的 本研究的目的是测试在工作和休闲期间进行的身体活动与全身炎症的相关程度。方法 有关工作经历和高敏 C 反应蛋白 (hs-CRP) 水平以及潜在混杂因素的数据来自哥本哈根老龄化和中年生物银行。与传统的自我报告的活动相比，参与者自我报告的工作经历与工作暴露矩阵相结合，以对累积的职业身体活动进行更有效的评估。职业体力活动以累积吨年来衡量（每天举起 1000 公斤，持续一年）。当前的休闲时间身体活动被自我报告为四个不同的类别。我们分析了职业体育活动之间的关联，多变量线性回归模型中的当前休闲时间体力活动和 hs-CRP 水平，并调整了年龄、性别、吸烟史、慢性病数量、体重指数和酒精。结果 在未经调整的分析中，较高的职业体育活动与较高的 hs-CRP 水平相关，而较高的休闲时间体育活动与较低的 hs-CRP 水平相关。在调整后的分析中，较低的休闲时间体育活动导致 hs-CRP 水平升高 12%，而较高的职业体育活动显示 hs-CRP 水平提高 6%。当我们将职业和休闲时间的身体活动作为连​​续变量进行分析时，只有休闲时间的身体活动会影响 hs-CRP。结论 本研究表明，体力活动与 hs-CRP 之间的关系取决于体力活动的设置，与休闲时间体育活动相关的 hs-CRP 较低，与职业体育活动相关的 hs-CRP 较高。结果表明，全身炎症可以解释身体活动悖论。可根据合理要求提供数据。向 CAMB 的 PI 提出请求。更多信息可从.