Fine-mapping and replication of EWAS loci harboring putative epigenetic alterations associated with AD neuropathology in a large collection of human brain tissue samples,Alzheimer's & Dementia

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Fine-mapping and replication of EWAS loci harboring putative epigenetic alterations associated with AD neuropathology in a large collection of human brain tissue samples
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-08-12 , DOI: 10.1002/alz.12761
Helena Palma-Gudiel ₁ , Lei Yu ₂ , Zhiguang Huo ₃ , Jingyun Yang ₂ , Yanling Wang ₂ , Tongjun Gu ₄ , Cheng Gao ₁ , Philip L De Jager ₅ , Peng Jin ₆ , David A Bennett ₂ , Jinying Zhao ₁

Affiliation

Our previous epigenome-wide association study (EWAS) of Alzheimer's disease (AD) in human brain identified 71 CpGs associated with AD pathology. However, due to low coverage of the Illumina platform, many important CpGs might have been missed.

中文翻译：

在大量人类脑组织样本中对含有与 AD 神经病理学相关的假定表观遗传改变的 EWAS 基因座进行精细定位和复制

我们之前对人脑阿尔茨海默氏病 (AD) 进行的表观基因组关联研究 (EWAS) 确定了 71 个与 AD 病理相关的 CpG。然而，由于 Illumina 平台的覆盖率较低，许多重要的 CpG 可能被遗漏。

更新日期：2022-08-12

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