Using the methodology of “click” chemistry, a series of conjugates of 3,5-bis(benzylidene)-1-(prop-2-yn)piperidin-4-ones with 4-alkyl-3-azidomethyl-2-ethoxy-2,5-dihydro-5H-1,2 oxaphosphol 2-oxides was synthesized. All newly obtained compounds 8–18 were characterized by ¹H, ¹³C, ³¹P, ¹⁹F NMR and IR spectroscopy. The potential antitumor activity of the synthesized conjugates 8–18 was studied in terms of their ability to influence the viability of various cancer cell lines, including A549, SH-SY5Y, Hep-2, and HeLa. Compound 15, which contains two fluorine atoms in the benzene ring, was shown to be the most promising. The mechanism of the cytotoxic action of this conjugate is supposed to be associated with the ability to inhibit the glycolytic profile of transformed cells.

使用“点击”化学方法，3,5-bis(benzylidene)-1-(prop-2-yn)piperidin-4-ones 与 4-alkyl-3-azidomethyl-2-ethoxy- 的一系列共轭物合成了 2,5-dihydro-5H-1,2 oxaphosphol 2-oxides。所有新获得的化合物8 – 18均通过¹ H、¹³ C、³¹ P、¹⁹ F NMR 和 IR 光谱进行了表征。根据其影响各种癌细胞系（包括 A549、SH-SY5Y、Hep-2 和 HeLa）活力的能力，研究了合成的缀合物 8-18 的潜在抗肿瘤活性。化合物15    ，在苯环中包含两个氟原子，被证明是最有希望的。该偶联物的细胞毒作用机制被认为与抑制转化细胞糖酵解谱的能力有关。