Manufacturing thiazolidinediones in a batch process is often carried out at different locations, where each successive batch collects a certain amount of intermediate followed by its transportation to another location. Thiazolidinediones containing APIs are unstable at ambient temperature. In this regard, manufacturing sites need huge storage capacity with lower temperature (2–8 °C), which eventually increases the production cost. Another problem with the individual batch mode is regarding the strict regulatory control to monitor successive batches. If any batch product parameter doesn't match with the regulatory approved specification, then the entire batch must be discarded or reprocessed, which results in high manufacturing price and renders it unaffordable. Herein, we have developed an integrated continuous flow nucleophilic substitution, Knoevenagel condensation, and hydrogenation reaction (NKH) platform for the on-demand production of thiazolidinediones in 32.5 min residence time with an overall improved yield.

中文翻译：

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用于按需合成罗格列酮和吡格列酮的集成连续流平台的组装

批量生产噻唑烷二酮类化合物通常在不同地点进行，其中每个连续批次收集一定量的中间体，然后将其运输到另一个地点。含有 API 的噻唑烷二酮类化合物在环境温度下不稳定。在这方面，制造场所需要具有较低温度（2-8°C）的巨大存储容量，这最终会增加生产成本。单个批次模式的另一个问题是关于监控连续批次的严格监管控制。如果任何批次产品参数与监管批准的规格不匹配，则必须将整批产品丢弃或重新加工，这会导致制造价格高昂并使其无法承受。在这里，我们开发了一种集成的连续流动亲核取代，