Objective. To investigate the serum levels of CXC chemokine 13 (CXCL-13), retinol binding protein-4 (RBP-4), and interleukin 6 (IL-6) in patients with Graves’ disease (GD). The correlation between CXCL-13, RBP-4, and IL-6 levels and the basal metabolic rate (BMR) was analyzed. Methods. 118 GD patients diagnosed in our hospital were selected as the observation group from March 2017 to December 2018. According to the measured BMR value, 118 GD patients were divided into the mild group (n = 39), the moderate group (n = 47), and the severe group (n = 32), three subgroups. 60 healthy subjects were selected as the control group. The serum levels of CXCL-13, RBP-4, IL-6, TSH, FT3, and FT4 in every group were measured. Pearson correlation analysis was used to observe the correlation of serum CXCL-13, RBP-4, and IL-6 levels with TSH, FT3, FT4, and BMR. Results. The levels of serum CXCL-13, RBP-4, and IL-6 in the observation group were higher than those of the control group, and the differences were statistically significant (). The levels of serum CXCL-13, RBP-4, and IL-6 in the moderate and severe groups were higher than those in the mild group, and the differences were statistically significant (). The levels of serum CXCL-13, RBP-4, and IL-6 in the severe group were higher than those in the moderate group, and the differences were statistically significant (). Pearson correlation analysis showed that the serum levels of CXCL-13, RBP-4, and IL-6 in GD patients were negatively correlated with TSH levels and positively correlated with FT3 and FT4 levels. Serum CXCL-13, RBP-4, and IL-6 levels in GD patients were positively correlated with BMR (r = 0.915, r = 0.942, r = 0.926, ). Conclusion. Serum CXCL-13, RBP-4, and IL-6 levels are elevated in patients with GD, and with the aggravation of the disease, the serum CXCL-13, RBP-4, and IL-6 levels also increase, showing a positive correlation, which can be used as indicators to reflect the degree of GD.

中文翻译：

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Graves病患者血清CXCL-13、RBP-4、IL-6水平与相关性分析

客观。研究 Graves 病 (GD) 患者的血清 CXC 趋化因子 13 (CXCL-13)、视黄醇结合蛋白-4 (RBP-4) 和白细胞介素 6 (IL-6) 水平。分析了CXCL-13、RBP-4、IL-6水平与基础代谢率（BMR）的相关性。方法。选取2017年3月至2018年12月在我院确诊的118例GD患者作为观察组。根据测得的BMR值将118例GD患者分为轻度组（n  =39）、中度组（n  =47） , 重度组 ( n = 32），三个子组。选取60名健康受试者作为对照组。测定各组血清CXCL-13、RBP-4、IL-6、TSH、FT3、FT4水平。采用Pearson相关分析观察血清CXCL-13、RBP-4、IL-6水平与TSH、FT3、FT4、BMR的相关性。结果。观察组血清CXCL-13、RBP-4、IL-6水平均高于对照组，差异有统计学意义（）。中、重度组血清CXCL-13、RBP-4、IL-6水平均高于轻度组，差异有统计学意义。）。重度组血清CXCL-13、RBP-4、IL-6水平高于中度组，差异有统计学意义。）。Pearson相关分析显示，GD患者血清CXCL-13、RBP-4、IL-6水平与TSH水平呈负相关，与FT3、FT4水平呈正相关。GD患者血清CXCL-13、RBP-4、IL-6水平与BMR呈正相关（ r  =0.915， r  =0.942， r  =0.926，）。 结论。GD患者血清CXCL-13、RBP-4、IL-6水平升高，且随着病情加重，血清CXCL-13、RBP-4、IL-6水平也升高，呈阳性相关性，可以作为反映GD程度的指标。