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Controlled tough bioadhesion mediated by ultrasound
Science ( IF 56.9 ) Pub Date : 2022-08-11 , DOI: 10.1126/science.abn8699
Zhenwei Ma 1 , Claire Bourquard 2 , Qiman Gao 3 , Shuaibing Jiang 1 , Tristan De Iure-Grimmel 4 , Ran Huo 1 , Xuan Li 1 , Zixin He 1 , Zhen Yang 1 , Galen Yang 5 , Yixiang Wang 6 , Edmond Lam 5, 7 , Zu-Hua Gao 8 , Outi Supponen 2 , Jianyu Li 1, 9
Affiliation  

Tough bioadhesion has important implications in engineering and medicine but remains challenging to form and control. We report an ultrasound (US)–mediated strategy to achieve tough bioadhesion with controllability and fatigue resistance. Without chemical reaction, the US can amplify the adhesion energy and interfacial fatigue threshold between hydrogels and porcine skin by up to 100 and 10 times. Combined experiments and theoretical modeling suggest that the key mechanism is US-induced cavitation, which propels and immobilizes anchoring primers into tissues with mitigated barrier effects. Our strategy achieves spatial patterning of tough bioadhesion, on-demand detachment, and transdermal drug delivery. This work expands the material repertoire for tough bioadhesion and enables bioadhesive technologies with high-level controllability.

中文翻译:

由超声介导的可控的强生物粘附

艰难的生物粘附在工程和医学中具有重要意义,但仍然难以形成和控制。我们报告了一种超声(US)介导的策略,以实现具有可控性和抗疲劳性的强生物粘附性。在不发生化学反应的情况下,美国可以将水凝胶与猪皮肤之间的粘附能和界面疲劳阈值放大高达 100 和 10 倍。结合实验和理论模型表明,关键机制是 US 诱导的空化,它将锚定引物推进并固定到组织中,并减轻屏障效应。我们的策略实现了强生物粘附、按需分离和透皮给药的空间模式。这项工作扩展了坚韧生物粘附的材料库,并实现了具有高度可控性的生物粘附技术。
更新日期:2022-08-11
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