当前位置: X-MOL 学术Drug Des. Dev. Ther. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial
Drug Design, Development and Therapy ( IF 4.8 ) Pub Date : 2022-08-12 , DOI: 10.2147/dddt.s377237
Song Hu 1, 2, 3 , Mingxia Wang 2, 3 , Siyu Li 2 , Wenyu Zhou 3 , Yi Zhang 2 , Haobing Shi 2 , Pengcheng Ye 2 , Jixiong Sun 2 , Feng Liu 2 , Wei Zhang 2 , Li Zheng 3 , Qianhao Hou 2 , Yue Wang 2 , Weixin Sun 2 , Yuanli Chen 2 , Zhenzhen Lu 4 , Zhonghua Ji 2 , Lijun Liao 2 , Xin Lv 3 , Yinglin Wang 2 , Xiangrui Wang 2 , Hao Yang 2, 3
Affiliation  

Objective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.
Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.
Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.
Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.

Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation


中文翻译:

静脉注射利多卡因显着降低接受胃镜检查的老年患者的丙泊酚剂量:一项随机对照试验

目的:基于丙泊酚的镇静剂已广泛用于胃镜检查,但老年患者呼吸抑制的风险不容忽视。手术期间静脉注射(IV)利多卡因可以减少对丙泊酚的需求和心肺并发症的发生率。我们检查了静脉注射利多卡因是否会减少老年患者胃镜检查期间异丙酚的剂量和不良事件的发生。
方法:我们对年龄≥65 岁的 ASA I-II 老年患者进行了一项前瞻性、单中心、双盲随机对照试验。受试者被随机分配到利多卡因组(L 组,n=70),他们接受静脉注射 1.5 mg kg - 1利多卡因,然后连续输注 4 mg kg - 1 h - 1利多卡因或生理盐水组(N 组,n=70),他们以相同的方式接受等量的生理盐水。
结果: IV 利多卡因降低了 L 组丙泊酚的总剂量和维持剂量(p < 0.001),对诱导剂量没有显着影响。术中缺氧(p =0.035)、紧急气道管理事件(p =0.005)、胃镜检查时间(p <0.05)、意识恢复时间(p <0.001)和术后疼痛(p =0.009)均减少L组患者(p = 0.025)和胃镜检查者(p=0.031) L组满意度较高。两组术中血流动力学参数、呼吸频率、镇静相关事件发生率和麻醉医师满意度相似。
结论:静脉注射利多卡因可显着降低老年患者胃镜检查中丙泊酚用量、缺氧发生率及术后疼痛,患者及胃镜医师满意度较高。

关键词:利多卡因 丙泊酚 胃镜检查 老年患者 镇静
更新日期:2022-08-12
down
wechat
bug