The mammalian liver harbors heterogeneous cell types that communicate via local paracrine signaling. Recent studies have delineated the transcriptomic landscape of the liver in NASH that provides insights into liver cell heterogeneity, intercellular crosstalk, and disease-associated reprogramming. However, the nature of intrahepatic signaling and its role in NASH progression remain obscure.

中文翻译：

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心肌营养素样细胞因子因子 1 的肝内旁分泌信号可改善小鼠饮食诱导的 NASH

哺乳动物肝脏含有通过局部旁分泌信号传导进行交流的异质细胞类型。最近的研究描绘了 NASH 中肝脏的转录组图谱，为了解肝细胞异质性、细胞间串扰和疾病相关重编程提供了见解。然而，肝内信号传导的性质及其在 NASH 进展中的作用仍然不清楚。