CST is both an ssDNA-binding complex and a DNA Pol-α/primase cofactor that coordinates the switch from G-strand elongation to C-strand fill-in during telomere maintenance. Four papers in Nature Structural & Molecular Biology and Nature provide transformative insights into CST activity, providing a platform to understand lagging-strand synthesis genome wide.

中文翻译：

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填补空白：使用 CST 复制端粒时 C 链如何赶上 G 链

CST 既是一种 ssDNA 结合复合物，又是一种 DNA Pol-α/引物酶辅助因子，可在端粒维持过程中协调从 G 链伸长到 C 链填充的转换。《Nature Structural & Molebiology》和《Nature》上的四篇论文提供了对 CST 活动的变革性见解，为理解全基因组范围内的滞后链合成提供了一个平台。