Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging,Journal of Nanobiotechnology

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Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging
Journal of Nanobiotechnology ( IF 10.2 ) Pub Date : 2022-08-11 , DOI: 10.1186/s12951-022-01566-8
Meng Wu _{1,

2,

3} , Yican Guo _{1,

2,

3} , Simin Wei _{1,

2,

3} , Liru Xue _{1,

2,

3} , Weicheng Tang _{1,

2,

3} , Dan Chen _{1,

2,

3} , Jiaqiang Xiong ₄ , Yibao Huang _{1,

2,

3} , Fangfang Fu _{1,

2,

3} , Chuqing Wu _{1,

2,

3} , Ying Chen _{1,

2,

3} , Su Zhou _{1,

2,

3} , Jinjin Zhang _{1,

2,

3} , Yan Li _{1,

2,

3} , Wenwen Wang _{1,

2,

3} , Jun Dai _{1,

2,

3} , Shixuan Wang _{1,

2,

3}

Affiliation

Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation.

中文翻译：

评估和治疗卵巢衰老的生物材料和先进技术

卵巢衰老的特点是卵巢功能逐渐下降。随着全球预期寿命的延长，卵巢衰老逐渐成为女性的主要健康问题。多年来，已经制定了各种策略来保持女性的生育能力，而目前还没有临床治疗可以延缓卵巢衰老。最近，生物材料和技术的进步，例如用于包裹卵泡和纳米颗粒作为药物递送系统的三维 (3D) 打印和微流体，已显示出潜在的卵巢衰老转化策略。本综述介绍了卵巢衰老机制的研究进展，总结了生物材料在卵巢衰老评估和治疗中的现状，包括安全性、潜在应用、

更新日期：2022-08-11

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