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Characteristics of Semiautomated Endothelial Cell-Density Measurements Among Corneal Donor Eyes.
JAMA Ophthalmology ( IF 8.1 ) Pub Date : 2022-09-01 , DOI: 10.1001/jamaophthalmol.2022.2782
Wuqaas M Munir 1 , Saleha Z Munir 1
Affiliation  

Importance Endothelial cell density in corneal donor eyes remains a critical component in selecting tissue suitable for corneal transplant. Objective To describe an anomaly in endothelial cell density discovered in a large cohort of corneal donor eyes. Design, Setting, and Participants Donor information for this cross-sectional study was obtained from the CorneaGen eye bank for donors from June 1, 2012, to June 30, 2016. Endothelial cell density was reported by eye bank technicians for each eye. The retrospective donor data set included donor demographics, endothelial cell count, time of death, medical and surgical history, and suitability for transplant. The donor data set contained information on donated eyes over the 4-year period. Main Outcomes and Measures Endothelial cell-density heat map, 2-dimensional binned plots, and bayesian change point analysis. Results A total of 48 207 donated eyes were evaluated. Mean (SD) cell count was 2717 (448) cells/mm2, and mean (SD) donor age was 58 (13) years. Heat maps using 2-dimensional binned plots demonstrated accentuated endothelial cell density results particularly at and immediately above 2500 cells/mm2 with a small gap right under this figure. A bayesian change point analysis revealed a change point at exactly this location as well. Conclusions and Relevance Data from this cross-sectional study suggest a discontinuity in endothelial cell-density measurements just below 2500 cells/mm2. This anomaly suggests that the semiautomated counting technique used in this cohort preferentially skipped over measurements just below this cutoff. Whether this represents an automation error, or more likely, a subjective human bias, requires further study.

中文翻译:

角膜供体眼睛半自动内皮细胞密度测量的特征。

重要性 角膜供体眼中的内皮细胞密度仍然是选择适合角膜移植的组织的关键因素。目的 描述在一大群角膜供体眼中发现的内皮细胞密度异常。设计、设置和参与者 这项横断面研究的捐赠者信息是从2012年6月1日至2016年6月30日期间从 CorneaGen 眼库获得的捐赠者。眼库技术人员报告了每只眼睛的内皮细胞密度。回顾性捐献者数据集包括捐献者人口统计、内皮细胞计数、死亡时间、医疗和手术史以及移植适宜性。捐赠者数据集包含 4 年期间捐赠眼睛的信息。主要成果和措施内皮细胞密度热图、二维分箱图和贝叶斯变化点分析。结果 总共对 48 207 只捐献眼睛进行了评估。平均 (SD) 细胞计数为 2717 (448) 个细胞/mm2,平均 (SD) 供体年龄为 58 (13) 岁。使用二维分箱图的热图表明,内皮细胞密度结果特别明显,特别是在 2500 个细胞/mm2 及以上时,在该图的正下方有一个小间隙。贝叶斯变化点分析也揭示了恰好在这个位置的变化点。结论和相关性 这项横断面研究的数据表明内皮细胞密度测量值不连续,略低于 2500 个细胞/mm2。这种异常现象表明,该队列中使用的半自动计数技术优先跳过略低于此截止值的测量。这是否代表自动化错误,或更可能代表人类主观偏见,需要进一步研究。
更新日期:2022-07-28
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