A simple, rapid method using CE and microchip electrophoresis with C⁴D has been developed for the separation of four nonsteroidal anti-inflammatory drugs (NSAIDs) in the environmental sample. The investigated compounds were ibuprofen (IB), ketoprofen (KET), acetylsalicylic acid (ASA), and diclofenac sodium (DIC). In the present study, we applied for the first time microchip electrophoresis with C⁴D detection to the separation and detection of ASA, IB, DIC, and KET in the wastewater matrix. Under optimum conditions, the four NSAIDs compounds could be well separated in less than 1 min in a BGE composed of 20 mM His/15 mM Tris, pH 8.6, 2 mM hydroxypropyl-beta-cyclodextrin, and 10% methanol (v/v) at a separation voltage of 1000–1200 V. The proposed method showed excellent repeatability, good sensitivity (LODs ranging between 0.156 and 0.6 mg/L), low cost, high sample throughputs, portable instrumentation for mobile deployment, and extremely lower reagent and sample consumption. The developed method was applied to the analysis of pharmaceuticals in wastewater samples with satisfactory recoveries ranging from 62.5% to 118%.

中文翻译：

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毛细管电泳和微芯片电泳电容耦合非接触电导检测法快速测定废水中的非甾体抗炎药

开发了一种使用毛细管电泳和含 C ⁴ D 的微芯片电泳的简单、快速的方法，用于分离环境样品中的四种非甾体类抗炎药 (NSAID)。研究的化合物是布洛芬 (IB)、酮洛芬 (KET)、乙酰水杨酸 (ASA) 和双氯芬酸钠 (DIC)。本研究首次应用C ^{4微芯片电泳}D检测对废水基质中ASA、IB、DIC、KET的分离检测。在最佳条件下，在由 20 mM His/15 mM Tris、pH 8.6、2 mM 羟丙基-β-环糊精和 10% 甲醇 (v/v) 组成的 BGE 中，可以在不到 1 分钟的时间内很好地分离四种 NSAIDs 化合物在 1000–1200 V 的分离电压下。所提出的方法显示出出色的重复性、良好的灵敏度（LOD 范围在 0.156 和 0.6 mg/L 之间）、低成本、高样品通量、用于移动部署的便携式仪器以及极低的试剂和样品消耗。将开发的方法应用于废水样品中药物的分析，回收率在 62.5% 到 118% 之间，令人满意。