Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures – that is, the exposome – is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study.

中文翻译：

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基因组和暴露组对青少年心理健康影响的综合分析

需要了解对年轻人心理健康问题的复杂影响，以便为早期预防策略提供信息。众所周知，遗传和环境因素都会影响青少年的心理健康，但需要更全面地了解它们之间的相互作用，包括广泛的环境暴露——即暴露组。我们对来自青少年大脑和认知发展 (ABCD) 研究的 4,314 名无关青年的队列中与内化和外化症状相关的基因组和暴露组数据进行了综合分析。