BACKGROUND: Postural disorders are frequently observed in Parkinson’s disease (PD). The underlying mechanisms that cause postural disorders are not fully understood and the majority of these disorders have no response to antiparkinsonian treatments. These disabling conditions require further investigation to better understand the underlying mechanisms in order to develop effective treatments. OBJECTIVE: The aim of this study was to investigate the frequency of axial postural disorders in PD and to determine the associated clinical risk factors. METHODS:In this single-center clinical trial, the data of PD patients were reviewed retrospectively. The frequencies of postural disorders were determined, and the demographic clinical characteristics of the patients were compared. RESULTS: The records of 127 patients with idiopathic PD were analyzed. Axial posture disorders were found in 42.6% of patients. Patients with axial posture disorders were older when the disease onset was detected, amongst these patients the condition was also longer lasting. The mean levodopa dose was higher in the patients with posture disorders. The initial symptom was bradykinesia and the Hoehn and Yahr’s score was ⩾ 3 in the majority of the patients with posture disorder. Additionally, constipation, hallucinations, postural instability, and falls were significantly more common in patients with posture disorders. CONCLUSION: Posture disorders were observed in nearly half of PD patients and were more frequently observed in patients with an advanced condition. In addition, our investigation has found that it is crucial to follow up with patients who present with bradykinesia for the development of postural disorder.

中文翻译：

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帕金森病的轴向姿势障碍：临床相关性和未来治疗方向 1

背景：在帕金森病 (PD) 中经常观察到姿势障碍。导致姿势障碍的潜在机制尚不完全清楚，并且大多数这些障碍对抗帕金森病治疗没有反应。这些致残情况需要进一步调查，以更好地了解潜在机制，从而开发出有效的治疗方法。目的：本研究的目的是调查 PD 中轴向姿势障碍的频率并确定相关的临床危险因素。方法：在这项单中心临床试验中，回顾性回顾了 PD 患者的资料。确定了姿势障碍的频率，并比较了患者的人口统计学临床特征。结果：对 127 名特发性 PD 患者的病历进行了分析。42.6% 的患者存在轴向姿势障碍。当检测到疾病发作时，患有轴向姿势障碍的患者年龄较大，在这些患者中，病情持续时间也更长。姿势障碍患者的平均左旋多巴剂量较高。最初的症状是运动迟缓，大多数姿势障碍患者的 Hoehn 和 Yahr 评分为  3。此外，便秘、幻觉、姿势不稳和跌倒在姿势障碍患者中更为常见。结论：在近一半的 PD 患者中观察到姿势障碍，并且在晚期患者中更常见。此外，我们的调查发现，对出现运动迟缓的患者进行随访对于姿势障碍的发展至关重要。