To determine the specific types, durations, and intensities of recreational physical activity associated with the greatest improvements in disease-free survival (DFS) of patients with colon cancer.

We conducted a prospective cohort study nested within a randomized multicenter trial of stage III colon cancer that compared 3 versus 6 months of fluorouracil, leucovorin, and oxaliplatin with or without celecoxib. We measured recreational physical activity in the first 3 months of chemotherapy and again 6 months after completion of chemotherapy. The primary end point was DFS.

During a median follow-up of 5.9 years, 457 of 1,696 patients experienced disease recurrence or death. For total recreational physical activity volume, the 3-year DFS was 76.5% with < 3.0 metabolic equivalent task hours per week (MET-h/wk) and 87.1% with ≥ 18.0 MET-h/wk (risk difference [RD], 10.6%; 95% CI, 4.7 to 19.4; P < .001). For light-intensity to moderate-intensity activities, the 3-year DFS was 65.7% with 0.0 h/wk and 87.1% with ≥ 1.5 h/wk (RD, 21.4%; 95% CI, 9.2 to 37.1; P < .001). For vigorous-intensity activity, the 3-year DFS was 76.0% with 0.0 h/wk and 86.0% with ≥ 1.0 h/wk (RD, 10.0%; 95% CI, 4.5 to 18.9; P < .001). For brisk walking, the 3-year DFS was 81.7% with < 1.0 h/wk and 88.4% with ≥ 3.0 h/wk (RD, 6.7%; 95% CI, 3.0 to 13.8; P < .001). For muscle strengthening activity, the 3-year DFS was 81.8% with 0.0 h/wk and 88.8% for ≥ 0.5 h/wk (RD, 7.0%; 95% CI, 3.1 to 14.2; P = .003).

Among patients with stage III colon cancer enrolled in a trial of postoperative treatment, larger volumes of recreational physical activity, longer durations of light- to moderate-intensity aerobic physical activity, or any vigorous-intensity aerobic physical activity were associated with the greatest improvements in DFS.

确定与结肠癌患者无病生存 (DFS) 最大改善相关的娱乐性体育活动的具体类型、持续时间和强度。

我们在一项 III 期结肠癌随机多中心试验中进行了一项前瞻性队列研究，比较了 3 个月与 6 个月的氟尿嘧啶、亚叶酸和奥沙利铂联合或不联合塞来昔布的情况。我们在化疗的前 3 个月和化疗完成后 6 个月再次测量了娱乐性身体活动。主要终点是 DFS。

在中位随访 5.9 年期间，1,696 名患者中有 457 名经历了疾病复发或死亡。对于总娱乐体力活动量，每周 < 3.0 代谢当量任务小时 (MET-h/wk) 的 3 年 DFS 为 76.5%，≥ 18.0 MET-h/wk 的 3 年 DFS 为 87.1%（风险差异 [RD]，10.6） %；95% CI，4.7 至 19.4；P < .001）。对于轻度至中等强度的活动，每周 0.0 小时的 3 年 DFS 为 65.7%，每周 ≥ 1.5 小时的 3 年 DFS 为 87.1%（RD，21.4%；95% CI，9.2 至 37.1；P < .001 ）。对于高强度活动，0.0 小时/周的 3 年 DFS 为 76.0%，≥ 1.0 小时/周的 3 年 DFS 为 86.0%（RD，10.0%；95% CI，4.5 至 18.9；P < .001）。对于快走，每周 < 1.0 小时的 3 年 DFS 为 81.7%，每周 ≥ 3.0 小时的 3 年 DFS 为 88.4%（RD，6.7%；95% CI，3.0 至 13.8；P < .001）。对于肌肉强化活动，每周 0.0 小时的 3 年 DFS 为 81.8%，每周 ≥ 0.5 小时的 3 年 DFS 为 88.8%（RD，7.0%；95% CI，3.1 至 14.2；P = 0.003）。

在参加术后治疗试验的 III 期结肠癌患者中，较大量的娱乐性体育活动、较长时间的轻至中强度有氧体育活动或任何剧烈强度的有氧体育活动与术后预后的最大改善相关。 DFS。