FoxP3 is critical for regulatory T cell function and, thus, overall immune homeostasis. In this issue of Immunity, Leng et al. reveal how FoxP3 achieves specific recognition of DNA and functional specialization by adopting a head-to-head domain conformation.

中文翻译：

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FoxP3叉头二聚体：现在不要交换我

FoxP3 对调节性 T 细胞功能至关重要，因此对整体免疫稳态至关重要。在本期Immunity中，Leng 等人。揭示 FoxP3 如何通过采用头对头结构域构象实现对 DNA 的特异性识别和功能特化。