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Readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2022-08-08 , DOI: 10.1093/cid/ciac639
Kasper S Moestrup 1 , Joanne Reekie 1 , Adrian G Zucco 1 , Tomas Ø Jensen 1, 2 , Jens-Ulrik S Jensen 3, 4 , Lothar Wiese 5 , Sisse R Ostrowski 4, 6 , Carsten U Niemann 4, 7 , Cameron MacPherson 1 , Jens Lundgren 1, 4 , Marie Helleberg 1
Affiliation  

Background Many interventional in-patient COVID-19 trials assess primary outcomes through day 28 post-randomization. Since a proportion of patients experience protracted disease or relapse, such follow-up period may not fully capture the course of the disease, even when randomization occurs a few days after hospitalization. Methods Among adults hospitalized with COVID-19 in Eastern Denmark from March 18, 2020 - January 12, 2021 we assessed: all-cause mortality, recovery and sustained recovery 90 days after admission, and readmission and all-cause mortality 90 days after discharge. Recovery was defined as hospital discharge and sustained recovery as recovery and alive without readmissions for 14 consecutive days. Results Among 3,386 patients included in the study 2,796 (82.6%) reached recovery and 2,600 (77.0%) achieved sustained recovery. Of those discharged from hospital, 556 (19.9%) were readmitted, and 289 (10.3%) died. Overall, the median time to recovery was 6 days (Interquartile range (IQR), 3-10), and 19 days (IQR, 11-33) among patients in intensive care in the first two days of admission. Conclusions Post-discharge readmission and mortality rates were substantial. Therefore, sustained recovery should be favored to recovery outcomes in clinical COVID-19 trials. A 28-day follow-up period may be too short the critically ill.

中文翻译:

因 COVID-19 入院的患者的再入院、出院后死亡率和持续康复

背景 许多介入性住院患者 COVID-19 试验评估了随机化后第 28 天的主要结果。由于部分患者经历了长期疾病或复发,因此即使在住院后几天进行随机分组,这样的随访期也可能无法完全掌握疾病的进程。方法 在 2020 年 3 月 18 日至 2021 年 1 月 12 日期间在丹麦东部因 COVID-19 住院的成年人中,我们评估了:入院后 90 天的全因死亡率、康复和持续康复,以及出院后 90 天的再入院和全因死亡率。恢复被定义为出院,持续恢复被定义为恢复和存活,连续 14 天没有再入院。结果 在纳入研究的 3,386 名患者中,2,796 名 (82.6%) 达到康复,2,600 名 (77.0%) 达到持续康复。在出院的患者中,556 人(19.9%)再次入院,289 人(10.3%)死亡。总体而言,入院前两天重症监护患者的中位恢复时间分别为 6 天(四分位距 (IQR),3-10)和 19 天(IQR,11-33)。结论 出院后再入院率和死亡率很高。因此,在临床 COVID-19 试验中,应有利于持续恢复以恢复结果。28 天的随访期对于重症患者来说可能太短了。持续恢复应该有利于恢复临床 COVID-19 试验的结果。28 天的随访期对于重症患者来说可能太短了。持续恢复应该有利于恢复临床 COVID-19 试验的结果。28 天的随访期对于重症患者来说可能太短了。
更新日期:2022-08-08
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