Swelling-based disintegration is considered important for drug release from tablets and can be modified with excipients called tablet disintegrants. Swelling of tablets occurs axially and radially, and most researchers have observed both these events separately using 2D images. In the current work, we have studied these events simultaneously instead of separately under a stereozoom microscope for tablet compacts composed of high proportions of disintegrants (sodium starch glycolate, SSG and croscarmellose sodium, CCS), using water as the disintegrating medium. A hypothesis is proposed for the measurements of radial and axial swellings from a single 2D image, as horizontal lengths based on trigonometric functions for a right-angle triangle. All predicted axial and radial lengths (as per proposed hypothesis) are found validated with respect to vernier calliper measurements for dry-tablet compacts with a minute error of 3.809%. The axial swelling is approximately fivefolds more than that of radial swelling on the basis of normalised lengths. No particular trend can be spotted exclusively in favour of a superdisintegrant; however, the CCS-based tablets have shown higher swelling as compared to SSG-based tablets. From the current studies, it is evident that both axial and radial dimensions are obtainable from single 2D stereozoom images and can be successfully implemented for swelling studies of tablets.

中文翻译：

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从由超级崩解剂组成的压片的二维立体变焦图像同时进行轴向和径向溶胀研究

基于溶胀的崩解被认为对药物从片剂中释放很重要，并且可以用称为片剂崩解剂的赋形剂进行修饰。药片的膨胀发生在轴向和径向，大多数研究人员使用 2D 图像分别观察了这两个事件。在目前的工作中，我们在立体变焦显微镜下同时研究了这些事件，而不是分别研究了由高比例崩解剂（羟基乙酸淀粉钠、SSG 和交联羧甲基纤维素钠、CCS）组成的压片，使用水作为崩解介质。提出了一个假设，用于测量单个 2D 图像的径向和轴向膨胀，作为基于直角三角形三角函数的水平长度。发现所有预测的轴向和径向长度（根据提出的假设）都根据干片剂压片的游标卡尺测量值进行了验证，微小误差为 3.809%。基于归一化长度，轴向膨胀大约是径向膨胀的五倍。没有发现任何特定趋势专门支持超级崩解剂；然而，与基于 SSG 的片剂相比，基于 CCS 的片剂表现出更高的溶胀性。从目前的研究来看，很明显轴向和径向尺寸都可以从单个 2D 立体缩放图像中获得，并且可以成功地用于片剂的溶胀研究。基于归一化长度，轴向膨胀大约是径向膨胀的五倍。没有发现任何特定趋势专门支持超级崩解剂；然而，与基于 SSG 的片剂相比，基于 CCS 的片剂表现出更高的溶胀性。从目前的研究来看，很明显轴向和径向尺寸都可以从单个 2D 立体缩放图像中获得，并且可以成功地用于片剂的溶胀研究。基于归一化长度，轴向膨胀大约是径向膨胀的五倍。没有发现任何特定趋势专门支持超级崩解剂；然而，与基于 SSG 的片剂相比，基于 CCS 的片剂表现出更高的溶胀性。从目前的研究来看，很明显轴向和径向尺寸都可以从单个 2D 立体缩放图像中获得，并且可以成功地用于片剂的溶胀研究。