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The role of matrix stiffness in cancer stromal cell fate and targeting therapeutic strategies
Acta Biomaterialia ( IF 9.7 ) Pub Date : 2022-08-07 , DOI: 10.1016/j.actbio.2022.08.005
Jiayun Wei 1 , Jia Yao 1 , Mengchao Yan 1 , Ye Xie 1 , Pinyan Liu 1 , Yongcui Mao 1 , Xun Li 2
Affiliation  

The tumor microenvironment (TME) is a complex macromolecular network filled with a series of stromal cells. It plays an important role in tumorigenesis, development, immune escape, drug resistance, and other processes and has received increasing attention in recent years. Currently, tumor cell-centered treatments are insufficient to eradicate malignancies, and researchers are constantly searching for better treatments. Over the past decade, the TME has been recognized as a rich resource for anti-cancer drug development. As a significant mechanical feature in the microenvironment of solid tumors, matrix stiffness is increased owing to stromal deposition and remodeling. The effect of matrix stiffness on cancer cells has been described in many studies, whereas its effect on cancer stromal cell fate has rarely been summarized. Therefore, this review discusses the relevant content and drug treatment studies targeting matrix stiffness.

Statement of significance

Biochemical and biophysical interactions between tumor cells, stromal cells, and the extracellular matrix (ECM) co-create a distinct tumor microenvironment (TME), which impacts disease outcome. In recent years, there has been a greater emphasis on the physical properties of the ECM, with matrix stiffness being one of the most thoroughly investigated. The matrix stiffness of solid tumors is now commonly acknowledged to be greater than that of normal tissues. Cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), and endothelial cells (ECs) can all respond to matrix stiffness. At the same time, our current understanding of the TME is insufficient, and an in-depth examination of interactions between ECM and cells could lead to the development of more efficient and specialized treatments.



中文翻译:

基质刚度在癌症基质细胞命运和靶向治疗策略中的作用

肿瘤微环境 (TME) 是一个充满一系列基质细胞的复杂大分子网络。它在肿瘤的发生、发展、免疫逃逸、耐药等过程中发挥着重要作用,近年来受到越来越多的关注。目前,以肿瘤细胞为中心的治疗方法不足以根除恶性肿瘤,研究人员正在不断寻找更好的治疗方法。在过去十年中,TME 已被公认为抗癌药物开发的丰富资源。作为实体瘤微环境中的一个重要机械特征,基质刚度由于基质沉积和重塑而增加。许多研究都描述了基质刚度对癌细胞的影响,而很少总结其对癌细胞基质细胞命运的影响。所以,

重要性声明

肿瘤细胞、基质细胞和细胞外基质 (ECM) 之间的生化和生物物理相互作用共同创造了一个独特的肿瘤微环境 (TME),这会影响疾病的结果。近年来,人们更加重视 ECM 的物理特性,其中基体刚度是研究最透彻的特性之一。现在普遍认为实体瘤的基质刚度大于正常组织的基质刚度。癌症相关成纤维细胞 (CAF)、肿瘤相关巨噬细胞 (TAM) 和内皮细胞 (EC) 都可以对基质硬度做出反应。同时,我们目前对 TME 的了解还不够,深入研究 ECM 和细胞之间的相互作用可能会导致开发更有效和专业的治疗方法。

更新日期:2022-08-07
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