The Carbon–Hydrogen–Oxygen symbiosis networks (CHOSYNs) belong to the latest trend of sustainable process design whose main purpose is the efficient use of energy and mass resources. Processes Intensification methodologies have been used to enhance the sustainability of several chemical processes; therefore, this work proposes to involve intensified processes in the synthesis of CHOSYNs to improve the sustainability of the network beyond the integration benefits. The main objective of this work is to evaluate the impact of incorporating intensified processes on the CHOSYN economic, environmental and safety performances. Due to the intensive energy use and low thermal efficiency in distillation sequences, the intensification is focused on these separation processes to improve energy efficiency and reduce operating costs. As a case study is proposed a CHOSYN with conventional processes; thermally couple equivalent configurations are obtained and optimized for suitable distillation sequences of the participant plants, then these sequences are integrated substituting the conventional ones in the final configuration of the CHOSYN. For the conventional and intensified solutions, the variable and fixed costs are determined, the eco-indicator 99 is used to evaluate the environmental aspect, and the safety of the process is assessed by the individual risk.

碳-氢-氧共生网络（CHOSYNs）属于可持续工艺设计的最新趋势，其主要目的是有效利用能源和大量资源。工艺强化方法已被用于提高几种化学工艺的可持续性；因此，这项工作建议在 CHOSYN 的合成中加入强化过程，以提高网络的可持续性，超越整合的好处。这项工作的主要目的是评估强化工艺对 CHOSYN 经济、环境和安全性能的影响。由于蒸馏过程中能源使用密集且热效率低，因此集中在这些分离过程上，以提高能源效率并降低运营成本。作为案例研究，提出了一种采用传统工艺的 CHOSYN；获得热电偶等效配置并针对参与工厂的合适蒸馏序列进行优化，然后将这些序列集成到 CHOSYN 的最终配置中以替代传统配置。对于常规和强化解决方案，确定可变成本和固定成本，生态指标 99 用于评估环境方面，过程安全性通过个体风险评估。