The exact etiology and pathogenesis of congenital pseudarthrosis of tibia (CPT) are not clear. Quantitative proteomics analysis plays a vital role in disease pathology research. Tandem mass tag (TMT)-based proteomics techniques were employed to identify and analyze the differentially expressed proteins (DEP) in the tibia periosteum tissues of CPT patients.

中文翻译：

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使用骨膜蛋白质组学分析儿童先天性胫骨假关节发病机制的新见解

先天性胫骨假关节（CPT）的确切病因和发病机制尚不清楚。定量蛋白质组学分析在疾病病理学研究中起着至关重要的作用。采用基于串联质量标签 (TMT) 的蛋白质组学技术来识别和分析 CPT 患者胫骨骨膜组织中的差异表达蛋白 (DEP)。