A rapid and sensitive ultra-performance liquid chromatography tandem mass spectrometry method for determination of anlotinib in plasma and dried blood spots: Method development, validation, and clinical application,Rapid Communications in Mass Spectrometry

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A rapid and sensitive ultra-performance liquid chromatography tandem mass spectrometry method for determination of anlotinib in plasma and dried blood spots: Method development, validation, and clinical application
Rapid Communications in Mass Spectrometry ( IF 2 ) Pub Date : 2022-08-02 , DOI: 10.1002/rcm.9372
Ji Zhang _{1,

2} , Wenzheng Wang _{1,

2} , Jiaqi Du ₃ , Cai Li _{1,

2} , Suyun Wang _{1,

2} , Yikai Han ₄ , Huafei Wang ₅ , Hong Zong ₄ , Zhe Cheng ₆ , Xin Tian _{1,

2}

Affiliation

Anlotinib is a multi-target tyrosine kinase inhibitor, approved in China for treating several cancer types. Dose individualization based on therapeutic drug monitoring (TDM) is a useful tool to reduce toxicity. However, it is not convenient for patients to go to hospital for routine TDM via venous blood sampling at a certain time.

更新日期：2022-08-02

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