The profiling of natural urinary peptides is a valuable indicator of kidney condition. While front-end separation limits the speed of peptidomic profiling, MS1-based results suffer from limited peptide coverage and specificity. Clinical studies on chronic kidney disease require an effective strategy to balance the trade-off between identification depth and throughput.

中文翻译：

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评估基于 MS1 的方法在尿样中分析具有临床相关性的天然肽的可靠性

天然尿肽的分析是肾脏状况的一个有价值的指标。虽然前端分离限制了肽组分析的速度，但基于 MS1 的结果受到肽覆盖率和特异性有限的影响。慢性肾病的临床研究需要一种有效的策略来平衡识别深度和吞吐量之间的权衡。