Full sequencing of the GBA1 gene in patients with Parkinson’s disease provides a wide screening of pathogenic variants, but less developed regions of the world, like Latin America, may have difficulties in performing full sequencing. We performed a systematic review with meta-analysis to explore the prevalence and the odds ratio of specific GBA1 variants in Parkinson’s disease in Latin America. We noted a lack of full sequencing GBA1 studies in Latin America.

中文翻译：

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拉丁美洲帕金森病患者缺乏完整的 GBA1 测序研究

帕金森病患者GBA1基因的全测序提供了对致病变异的广泛筛查，但世界欠发达地区，如拉丁美洲，可能难以进行全测序。我们通过荟萃分析进行了系统评价，以探索拉丁美洲帕金森病中特定GBA1变异的患病率和优势比。我们注意到拉丁美洲缺乏完整的GBA1测序研究。