Organophosphate (OP) insecticides represent one of the largest classes of sprayed insecticides in the U.S., and their use has been associated with various adverse health outcomes, including disorders of blood pressure regulation such as hypertension (HTN). In a study of 935 adults from the NHANES 2013–2014 cycle, we examined the relationship between systolic and diastolic blood pressure changes and urinary concentrations of three OP insecticides metabolites, including 3,5,6-trichloro-2-pyridinol (TCPy), oxypyrimidine, and para-nitrophenol. These metabolites correspond to the parent compounds chlorpyrifos, diazinon, and methyl parathion, respectively. Weighted, multivariable linear regression analysis while adjusting for potential confounders were used to model the relationship between OP metabolites and blood pressure. Weighted, multivariable logistic regression analysis was used to model the odds of HTN for quartile of metabolites. We observed significant, inverse association between TCPy on systolic blood pressure (β-estimate = -0.16, p < 0.001) and diastolic blood pressure (β-estimate = -0.15, p < 0.001). Analysis with para-nitrophenol revealed a significant, positive association with systolic blood pressure (β-estimate = 0.03, p = 0.02), and an inverse association with diastolic blood pressure (β-estimate = -0.09, p < 0.001). For oxypyrimidine, we observed significant, positive associations between systolic blood pressure (β-estimate = 0.58, p = 0.03) and diastolic blood pressure (β-estimate = 0.31, p < 0.001). Furthermore, we observed significant interactions between TCPy and ethnicity on systolic blood pressure (β-estimate = 1.46, p = 0.0036). Significant interaction terms were observed between oxypyrimidine and ethnicity (β-estimate = -1.73, p < 0.001), as well as oxypyrimidine and BMI (β-estimate = 1.51 p < 0.001) on systolic blood pressure, and between oxypyrimidine and age (β-estimate = 1.96, p = 0.02), race (β-estimate = -3.81 p = 0.004), and BMI on diastolic blood pressure (β-estimate = 0.72, p = 0.02). A significant interaction was observed between para-nitrophenol and BMI for systolic blood pressure (β-estimate = 0.43, p = 0.01), and between para-nitrophenol and ethnicity on diastolic blood pressure (β-estimate = 2.19, p = 0.006). Lastly, we observed a significant association between the odds of HTN and TCPy quartiles (OR = 0.65, 95% CI [0.43,0.99]). Our findings support previous studies suggesting a role for organophosphate insecticides in the etiology of blood pressure dysregulation and HTN. Future studies are warranted to corroborate these findings, evaluate dose–response relationships between organophosphate insecticides and blood pressure, determine clinical significance, and elucidate biological mechanisms underlying this association.

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有机磷杀虫剂与血压失调之间的关联：NHANES 2013–2014

有机磷 (OP) 杀虫剂是美国最大的喷洒杀虫剂类别之一，它们的使用与各种不良健康结果有关，包括高血压 (HTN) 等血压调节障碍。在一项针对 NHANES 2013-2014 周期的 935 名成年人的研究中，我们检查了收缩压和舒张压变化与三种 OP 杀虫剂代谢物尿液浓度之间的关系，包括 3,5,6-三氯-2-吡啶醇 (TCPy)、氧嘧啶和对硝基苯酚。这些代谢物分别对应于毒死蜱、二嗪农和甲基对硫磷的母体化合物。加权、多变量线性回归分析同时针对潜在混杂因素进行调整，用于模拟 OP 代谢物与血压之间的关系。加权，多变量逻辑回归分析用于模拟代谢物四分位数的 HTN 几率。我们观察到 TCPy 与收缩压（β-估计值 = -0.16，p < 0.001）和舒张压（β-估计值 = -0.15，p < 0.001）之间存在显着的负相关。对硝基苯酚的分析显示与收缩压呈显着正相关（β-估计值 = 0.03，p = 0.02），与舒张压呈负相关（β-估计值 = -0.09，p < 0.001）。对于氧嘧啶，我们观察到收缩压（β-估计值 = 0.58，p = 0.03）和舒张压（β-估计值 = 0.31，p < 0.001）之间存在显着正相关。此外，我们观察到 TCPy 和种族之间在收缩压方面的显着相互作用（β-估计值 = 1.46，p = 0.0036）。在氧嘧啶和种族（β-估计值 = -1.73，p < 0.001）之间，以及氧嘧啶和 BMI（β-估计值 = 1.51 p < 0.001）对收缩压以及氧嘧啶和年龄（β -estimate = 1.96，p = 0.02），种族（β-estimate = -3.81 p = 0.004）和 BMI 对舒张压的影响（β-estimate = 0.72，p = 0.02）。观察到对硝基苯酚和 BMI 对收缩压的显着相互作用（β-估计值 = 0.43，p = 0.01），以及对硝基苯酚和种族对舒张压的相互作用（β-估计值 = 2.19，p = 0.006）。最后，我们观察到 HTN 和 TCPy 四分位数的几率之间存在显着关联 (OR = 0.65, 95% CI [0.43,0.99])。我们的研究结果支持之前的研究，这些研究表明有机磷杀虫剂在血压失调和 HTN 的病因学中起作用。未来的研究有必要证实这些发现，评估有机磷杀虫剂与血压之间的剂量反应关系，确定临床意义，并阐明这种关联的生物学机制。