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The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-07-31 , DOI: 10.1002/alz.12756
Oskar Hansson 1, 2 , Rebecca M Edelmayer 3 , Adam L Boxer 4 , Maria C Carrillo 3 , Michelle M Mielke 5 , Gil D Rabinovici 4 , Stephen Salloway 6 , Reisa Sperling 7 , Henrik Zetterberg 8, 9, 10, 11, 12 , Charlotte E Teunissen 13
Affiliation  

Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological changes for inclusion in trials evaluating disease-modifying therapies, provided the AD status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing. We also encourage studying longitudinal BBM changes in ongoing as well as future interventional trials. However, BBMs should not yet be used as primary endpoints in pivotal trials. Further, we recommend to cautiously start using BBMs in specialized memory clinics as part of the diagnostic work-up of patients with cognitive symptoms and the results should be confirmed whenever possible with CSF or PET. Additional data are needed before use of BBMs as stand-alone diagnostic AD markers, or before considering use in primary care.

中文翻译:

阿尔茨海默病协会对阿尔茨海默病血液生物标志物的适当使用建议

基于血液的标记物 (BBM) 最近显示出有望彻底改变阿尔茨海默病 (AD) 的诊断和预后检查,以及改进介入试验的设计。在这里,我们详细讨论了在广泛使用 BBM 之前需要进行的进一步研究。我们现在已经推荐使用 BBM 作为(预)筛选器来识别可能患有 AD 病理变化的个体,以便将其纳入评估疾病改善疗法的试验中,前提是通过正电子发射断层扫描 (PET) 或脑脊液 (CSF) 确认 AD 状态)测试。我们还鼓励在正在进行的和未来的干预试验中研究纵向 BBM 变化。但是,BBM 尚不应该用作关键试验的主要终点。更远,我们建议在专门的记忆诊所开始谨慎使用 BBM 作为认知症状患者诊断检查的一部分,并且应尽可能使用 CSF 或 PET 确认结果。在使用 BBM 作为独立的诊断 AD 标志物之前,或在考虑用于初级保健之前,需要额外的数据。
更新日期:2022-07-31
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