Noble metals and their alloy-based nanomaterials are widely used in biomedicine, especially in the fields of photodynamic therapy (PDT) and photothermal therapy (PTT) on tumors, due to their remarkable physicochemical properties. Nonetheless, novel doping strategies with unexpected efficacies are still challenging and formidable. Herein, a photosensitizer-alloy nanosystem is designed for highly efficient PDT and PTT. Specifically, the optimized Pt/Ag alloy nanoparticles are facilely synthesized in one step at room temperature and are simultaneously endowed with enhanced peroxidase-like activity and photothermal conversion, and further activated cytotoxic singlet oxygen (¹O₂) productivity after covalent functionalization of chlorin e6 (Ce6). A small amount of Ag doping can kill two birds with one stone by simultaneously enhancing the synergistic PDT and PTT potential of Pt/Ag-PEG-Ce6 nanoparticles. Both in vitro and in vivo experimental results indicate that the significant temperature increase triggered by 808 nm laser and a large amount of toxic ¹O₂ excited by 671 nm laser synergistically and strongly kill tumor cells. Therefore, through proper doping and improved physicochemical properties, this nanosystem achieves effective PDT and PTT of tumors and also inspires the advanced design of noble metal-based nanomedicine.

中文翻译：

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具有增强的近红外吸收和类过氧化物酶活性的 Pt/Ag-PEG-Ce6 纳米系统用于协同光动力/光热疗法

贵金属及其合金基纳米材料由于其卓越的物理化学性质，被广泛应用于生物医学，尤其是肿瘤的光动力疗法（PDT）和光热疗法（PTT）领域。尽管如此，具有意想不到功效的新型兴奋剂策略仍然具有挑战性和艰巨性。在此，光敏剂合金纳米系统被设计用于高效的 PDT 和 PTT。具体而言，优化的 Pt/Ag 合金纳米粒子在室温下一步合成，同时具有增强的类过氧化物酶活性和光热转化，并进一步激活细胞毒性单线态氧 ( ¹ O ₂) 二氢卟酚 e6 (Ce6) 共价功能化后的生产力。少量Ag掺杂可以通过同时增强Pt/Ag-PEG-Ce6纳米粒子的协同PDT和PTT潜力，一石二鸟。体外和体内实验结果均表明，808 nm激光引起的显着升温和671 nm激光激发的大量毒性¹ O ₂协同强烈杀伤肿瘤细胞。因此，通过适当的掺杂和改善的物理化学性质，该纳米系统实现了肿瘤的有效PDT和PTT，也启发了贵金属基纳米药物的先进设计。