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6-Methylquinazolin-4(3H)-one Based Compounds as BRD9 Epigenetic Reader Binders: A Rational Combination of in silico Studies and Chemical Synthesis
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-08-05 , DOI: 10.1002/ejoc.202200868 Ester Colarusso 1 , Erica Gazzillo 1 , Eleonora Boccia 1 , Assunta Giordano 2 , Maria Giovanna Chini 3 , Giuseppe Bifulco 4 , Gianluigi Lauro 1
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-08-05 , DOI: 10.1002/ejoc.202200868 Ester Colarusso 1 , Erica Gazzillo 1 , Eleonora Boccia 1 , Assunta Giordano 2 , Maria Giovanna Chini 3 , Giuseppe Bifulco 4 , Gianluigi Lauro 1
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Five 6-methylquinazolin-4(3H)-one based compounds were here selected, efficiently synthesized, and identified as new BRD9 binders. These compounds selectively bind BRD9 epigenetic reader in the low micromolar range.
中文翻译：
6-甲基喹唑啉-4(3H)-one 基于化合物作为 BRD9 表观遗传阅读器粘合剂：计算机研究和化学合成的合理组合
五种基于 6-methylquinazolin-4(3 H )-one 的化合物在这里被选择、有效合成，并被确定为新的 BRD9 粘合剂。这些化合物在低微摩尔范围内选择性地结合 BRD9 表观遗传阅读器。
更新日期：2022-08-05
中文翻译：
6-甲基喹唑啉-4(3H)-one 基于化合物作为 BRD9 表观遗传阅读器粘合剂：计算机研究和化学合成的合理组合
五种基于 6-methylquinazolin-4(3 H )-one 的化合物在这里被选择、有效合成，并被确定为新的 BRD9 粘合剂。这些化合物在低微摩尔范围内选择性地结合 BRD9 表观遗传阅读器。
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