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Isolation of a Natural Killer Group 2D Small-Molecule Ligand from DNA-Encoded Chemical Libraries
ChemMedChem ( IF 3.4 ) Pub Date : 2022-08-05 , DOI: 10.1002/cmdc.202200350
Sheila Dakhel 1 , Andrea Galbiati 1 , Francesca Migliorini 1 , Claudia Comacchio 1 , Sebastian Oehler 1 , Luca Prati 1 , Jörg Scheuermann 2 , Samuele Cazzamalli 1 , Dario Neri 1 , Gabriele Bassi 1 , Nicholas Favalli 1
Affiliation  

Isolation of NKG2D Hit from DEL screening. Compact single-pharmacophore two-building block DNA-Encoded Chemical Libraries (DELs) containing in total more than 1 million compounds were screened against site-selective immobilized Natural Killer Group 2D (NKG2D). Compound 17, preferential enriched after DEL selection experiments was identified and validated as ligand of NKG2D with affinity constant in the nanomolar range.

中文翻译:

从 DNA 编码的化学文库中分离自然杀伤组二维小分子配体

从 DEL 筛选中分离 NKG2D 命中。针对位点选择性固定化 Natural Killer Group 2D (NKG2D) 筛选了包含总共超过 100 万种化合物的紧凑型单药团双结构单元 DNA 编码化学文库 (DEL)。在 DEL 选择实验后优先富集的化合物17被鉴定并验证为 NKG2D 的配体,其亲和常数在纳摩尔范围内。
更新日期:2022-08-05
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