Objective:To investigate the application value of bone marrow megakaryocyte count, the proportion of megakaryocytes at each stage, and the platelet parameter in the clinical diagnosis of primary immune thrombocytopenia (ITP). Methods: The megakaryocyte and platelet parameter level in 62 ITP and 40 control group patients were compared and analyzed. Linear correlation analysis, Pearson correlation analysis, and ROC curves were performed for the correlation between megakaryocytes and platelet parameters. Results: Compared to the control group, the total number of megakaryocytes, the promegakaryocytes the granular megakaryocytes (GMeg), and naked megakaryocytes (NMeg), MPV, and P-LCR% in the ITP group increased. All differences were statistically significant (P<0.05). While the proportion of platelet-producing megakaryocytes (PMeg), PLT, and PCT decreased in the ITP group. These differences were statistically significant (P < 0.05). PLT was strongly positively correlated with PCT (r = 0.921, p<0.01). PCT was weakly positively with MPV (r = 0.309, p<0.05). MPV was positively correlated with P-LCR (r = 0.856, p<0.01). PDW was weakly positively correlated with P-LCR (r = 0.296, p<0.05) and Meg (r = 0.301, p<0.05), and negatively correlated with PMeg (r = -0.336, p<0.05). ROC curve analysis showed that PLT, PCT MPV and P-LCR% gave a high sensitivity（100.0%，81.0%，74.6%，90.5%，respectively.) and specificity (100.0%, 92.5%, 80.0%, 77.5%, respectively.) in diagnosis of ITP. Conclusion: The combined analysis of bone marrow megakaryocyte count, the proportion of megakaryocyte classification at each stage, and platelet parameters have an important reference value for auxiliary diagnosis of ITP.

目的：探讨骨髓巨核细胞计数、各期巨核细胞比例、血小板参数在原发性免疫性血小板减少症（ITP）临床诊断中的应用价值。方法：比较分析62例ITP和40例对照组患者的巨核细胞和血小板参数水平。对巨核细胞与血小板参数之间的相关性进行线性相关分析、Pearson相关分析和ROC曲线。结果：与对照组相比，ITP组巨核细胞总数、前巨核细胞、颗粒巨核细胞（GMeg）、裸巨核细胞（NMeg）、MPV和P-LCR%均增加。所有差异均具有统计学意义（P<0.05)。而 ITP 组中产生血小板的巨核细胞 (PMeg)、PLT 和 PCT 的比例下降。这些差异具有统计学意义（P < 0.05）。PLT 与 PCT 呈强正相关（r = 0.921，p<0.01）。PCT 与 MPV 呈弱阳性 (r = 0.309, p<0.05)。MPV 与 P-LCR 呈正相关（r = 0.856，p<0.01）。PDW与P-LCR（r = 0.296，p<0.05）和Meg（r = 0.301，p<0.05）呈弱正相关，与PMeg呈负相关（r = -0.336，p<0.05）。ROC曲线分析显示PLT、PCT MPV和P-LCR%具有较高的敏感性（分别为100.0%，81.0%，74.6%，90.5%）和特异性（分别为100.0%，92.5%，80.0%，77.5%） .) 在 ITP 的诊断中。结论：骨髓巨核细胞计数、各期巨核细胞分类比例、血小板参数等联合分析对ITP的辅助诊断具有重要的参考价值。