Natural products decursin and decursinol angelate were recently reported as benign fungicides for controlling rice blast. Inspired by the structural similarity of the cumarin compounds and gained hint from the skeletal motifs, we designed and prepared synthetic compounds to increase the natural product efficacy and evaluated their antifungal activities against various plant disease pathogens in vitro. Synthetically prepared compound 4 and 5 indeed suppressed the mycelial growth of B. cinerea, F. oxysporum, P. italicum, and R. quercus-mongolicae. Additionally, compound 5 effectively prevents the growth of C. coccodes and C. parasitica. Furthermore, both 4 and 5 possess better inhibitory activities on spore germination of F. oxysporum and M. oryzae than the natural product decursin and commercial pesticide Iprodione. These results suggest that the effect of the lead compound for plant disease protection can be improved by tuning the structure of the original natural product and decursinol chloroacrylates 4 and 5 are candidates for the control of F. oxysporum and M. oryzae.

中文翻译：

---

可用作杀菌剂的氯丙烯酸地草酚

最近报道了天然产物前胡素和当归当归素作为防治稻瘟病的良性杀菌剂。受香豆素化合物结构相似性的启发并从骨骼基序中获得提示，我们设计并制备了合成化合物以提高天然产物的功效，并在体外评估了它们对各种植物病原菌的抗真菌活性。合成制备的化合物 4 和 5 确实抑制了 B. cinerea、F. oxysporum、 P. italicum 和 R. quercus-mongolicae 的菌丝体生长。此外，化合物 5 有效地防止 C. coccodes 和 C. parasitica 的生长。此外，4和5对尖孢镰刀菌和米根霉孢子萌发的抑制活性均优于天然产物decursin和商品杀虫剂Iprodione。