Abstract

Recent studies suggest that Omeprazole, a widely used treatment for gastric acid-related disorders, may have a significant effect on human cognition. However, there is no consensus on the matter. Though some studies suggest the drug is associated with an increased risk of cognitive decline, memory impairment, and dementia, this issue has not been sufficiently studied. Therefore, the goal of this study was to investigate the cognitive impairments associated with long-term Omeprazole treatment, with a focus on memory, attention, and executive functions. Additionally, we sought to verify whether the duration of treatment was associated with the magnitude of the associated cognitive impairments. The sample consisted of 30 participants of both genders treated with Omeprazole (experimental group) and 30 participants who did not use the drug (control group). The cognitive assessment battery: Verbal Fluency, Rey Auditory-Verbal Learning, Attention Assessment Battery, Five Digit Test, Hayling Test, and NEUPSILIN Subtest. The groups were compared using Student’s T-tests, and the association between treatment duration and cognitive performance was examined using Pearson’s coefficients. The results showed significant group differences in verbal fluency, short-term episodic memory, selective attention, and executive functions. The duration of Omeprazole treatment was also positively associated with the magnitude of cognitive impairment.

摘要

最近的研究表明，奥美拉唑是一种广泛用于治疗胃酸相关疾病的药物，可能对人类认知产生显着影响。但是，在这个问题上没有达成共识。尽管一些研究表明该药物与认知能力下降、记忆障碍和痴呆的风险增加有关，但该问题尚未得到充分研究。因此，本研究的目的是调查与长期奥美拉唑治疗相关的认知障碍，重点是记忆力、注意力和执行功能。此外，我们试图验证治疗持续时间是否与相关认知障碍的程度相关。样本包括 30 名接受奥美拉唑治疗的男女参与者（实验组）和 30 名未使用该药物的参与者（对照组）。认知评估电池：语言流利度、Rey 听觉-语言学习、注意力评估电池、五位数测试、Hayling 测试和 NEUPSILIN 子测试。使用学生 T 检验对各组进行比较，并使用 Pearson 系数检查治疗持续时间与认知能力之间的关联。结果显示，在语言流利度、短期情景记忆、选择性注意和执行功能方面存在显着的组间差异。奥美拉唑治疗的持续时间也与认知障碍的程度呈正相关。五位数测试、Hayling 测试和 NEUPSILIN 子测试。使用学生 T 检验对各组进行比较，并使用 Pearson 系数检查治疗持续时间与认知能力之间的关联。结果显示，在语言流利度、短期情景记忆、选择性注意和执行功能方面存在显着的组间差异。奥美拉唑治疗的持续时间也与认知障碍的程度呈正相关。五位数测试、Hayling 测试和 NEUPSILIN 子测试。使用学生 T 检验对各组进行比较，并使用 Pearson 系数检查治疗持续时间与认知能力之间的关联。结果显示，在语言流利度、短期情景记忆、选择性注意和执行功能方面存在显着的组间差异。奥美拉唑治疗的持续时间也与认知障碍的程度呈正相关。