Introduction

Many scholars have explored the effect of cognitive stimulation therapy (CST) on dementia patients, however, due to different experimental designs and insufficient sample sizes, research results are inconsistent. Furthermore, there is a scarcity of high-quality quantitative results.

Objective

To assess the effectiveness of CST for improving cognition, quality of life (QoL) and neuropsychiatric symptoms in people with dementia (PwD).

Methods

Chinese and English databases were searched for randomized controlled trials (RCTs) between establishment of and April 2022, with another search done in May 2022. Finally, 10 studies on the application of CST in PwD for improving cognition, QoL, behavior, language and activities of daily living were reviewed.

Results

Based on the results of the 10 RCTs, CST significantly improved cognitive performance (MMSE: WMD = 1.98, 95% CI: 1.24–2.72, P<0.01), QoL (WMD = 3.12, 95% CI: 2.52–3.72, P<0.01), language (NLT: WMD = 2.71, 95% CI: 1.07–4.35, P<0.01) and activities of daily living (DAD: WMD = 7.27, 95% CI: 0.97–13.56, P<0.01) in PwD. However, no significant improvements in ADAS-Cog (WMD = 0.55, 95% CI: -3.04–4.14, P = 0.76), depression (SMD = -0.12,95% CI: -0.29–0.04, P = 0.15), anxiety (RAID: WMD = -1.05, 95% CI: -3.85–1.75, P = 0.46) or neuropsychiatric symptoms (NPI: WMD = 0.23, 95% CI: -2.62–3.07, P = 0.88) were found.

Conclusion

CST improved the cognitive ability, QoL, language and activities of daily living of PwD. However, the effect of neuropsychiatric symptoms on PwD requires further exploration.

中文翻译：

---

认知刺激疗法 (CST) 对痴呆症患者认知、生活质量和神经精神症状的有效性：荟萃分析

介绍

许多学者探讨了认知刺激疗法（CST）对痴呆患者的影响，但由于实验设计不同，样本量不足，研究结果并不一致。此外，缺乏高质量的定量结果。

客观的

评估 CST 在改善痴呆症患者 (PwD) 的认知、生活质量 (QoL) 和神经精神症状方面的有效性。

方法

在中英文数据库中检索了从成立到 2022 年 4 月的随机对照试验（RCTs），并在 2022 年 5 月进行了另一次检索。最后，10 项关于 CST 在 PwD 中应用以改善认知、生活质量、行为、语言和活动的研究日常生活进行了审查。

结果

根据 10 项 RCT 的结果，CST 显着改善认知能力（MMSE：WMD = 1.98，95% CI：1.24–2.72，P <0.01），生活质量（WMD = 3.12，95% CI：2.52–3.72，P < 0.01)、语言 (NLT: WMD = 2.71, 95% CI: 1.07–4.35, P <0.01) 和日常生活活动 (DAD: WMD = 7.27, 95% CI: 0.97–13.56, P <0.01) 在 PwD。然而，ADAS-Cog (WMD = 0.55, 95% CI: -3.04–4.14, P  = 0.76)、抑郁 (SMD = -0.12,95% CI: -0.29–0.04, P  = 0.15)、焦虑没有显着改善(RAID: WMD = -1.05, 95% CI: -3.85–1.75, P  = 0.46) 或神经精神症状 (NPI: WMD = 0.23, 95% CI: -2.62–3.07, P  = 0.88)。

结论

CST 改善了 PwD 的认知能力、生活质量、语言和日常生活活动。然而，神经精神症状对 PwD 的影响需要进一步探索。