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Cell death in skin function, inflammation, and disease
Biochemical Journal ( IF 4.1 ) Pub Date : 2022-08-12 , DOI: 10.1042/bcj20210606
Holly Anderton 1, 2 , Suhaib Alqudah 3, 4
Affiliation  

Cell death is an essential process that plays a vital role in restoring and maintaining skin homeostasis. It supports recovery from acute injury and infection and regulates barrier function and immunity. Cell death can also provoke inflammatory responses. Loss of cell membrane integrity with lytic forms of cell death can incite inflammation due to the uncontrolled release of cell contents. Excessive or poorly regulated cell death is increasingly recognised as contributing to cutaneous inflammation. Therefore, drugs that inhibit cell death could be used therapeutically to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We discuss the evidence for their role in skin inflammation and disease and discuss therapeutic opportunities for targeting the cell death machinery.

中文翻译:

皮肤功能、炎症和疾病中的细胞死亡

细胞死亡是一个必不可少的过程,在恢复和维持皮肤稳态方面起着至关重要的作用。它支持从急性损伤和感染中恢复并调节屏障功能和免疫。细胞死亡也会引发炎症反应。由于细胞内容物的不受控制的释放,细胞膜完整性的丧失以及溶解形式的细胞死亡会引发炎症。过度或调节不佳的细胞死亡越来越被认为是导致皮肤炎症的原因。因此,抑制细胞死亡的药物可用于治疗某些炎症性皮肤病。开发此类抑制剂的计划已经在进行中。在这篇综述中,我们概述了皮肤相关细胞死亡程序的机制;细胞凋亡,坏死性凋亡,焦亡,NETosis,和表皮终末分化程序,角质化。我们讨论了它们在皮肤炎症和疾病中作用的证据,并讨论了针对细胞死亡机制的治疗机会。
更新日期:2022-08-06
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